Genetic risk factors for schizophrenia associate with sleep spindle activity in healthy adolescents

Journal of Sleep Research
Ilona MerikantoAnu-Katriina Pesonen

Abstract

Schizophrenia has been associated with disturbed sleep, even before the onset of the disorder, and also in non-schizophrenic first-order relatives. This may point to an underlying genetic influence. Here we examine whether weighted polygenic risk scores (PRS) for schizophrenia are associated with sleep spindle activity in healthy adolescents. Our sample comes from a community-based cohort of 157 non-schizophrenic adolescents (57% girls) having both genetic data and an overnight sleep EEG measurement available. Based on a recent genome-wide association study, we calculated PRS for schizophrenia across the whole genome. We also calculated PRS for the CACNA1l gene region, which has been associated with both schizophrenia and sleep spindle formation. We performed an overnight sleep EEG at the homes of the participants. Stage two sleep spindles were detected using an automated algorithm. Sleep spindle amplitude, duration, intensity and density were measured separately for central and frontal derivations and for fast (13-16 Hz) and slow (10-13 Hz) spindles. PRS for schizophrenia was associated with higher fast spindle amplitude (p = 0.04), density (p = 0.006) and intensity (p = 0.04) at the central derivation, and PRS in the CACNA1l ...Continue Reading

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Citations

Jan 12, 2020·Genes, Brain, and Behavior·Anu-Katriina PesonenLiisa Kuula
Jul 25, 2019·International Journal of Molecular Sciences·Arturo AndradeLaura Londrigan
Oct 11, 2020·Early Intervention in Psychiatry·Feten Fekih-RomdhaneMajda Cheour

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