Impact of Advanced Maternal Age on Physiologic Adaptations to Pregnancy in Vervet Monkeys

BioRxiv : the Preprint Server for Biology
M. PlantMatthew A Quinn

Abstract

Context: The trend to delay pregnancy in the United States has resulted in the number of advanced maternal age (AMA) pregnancies to also increase. In humans, AMA is as-sociated with a variety of pregnancy-related pathologies such as preeclampsia (PE). While AMA is known to be a factor which contributes to the development of pregnancy-induced diseases, the molecular and cellular mechanisms giving rise to this phenom-enon are still very limited. This is due in part to lack of a pre-clinical model which has physiologic relevance to human pregnancy while also allowing control of environmen-tal and genetic variability inherent in human studies. Objective: To determine potential physiologic relevance of the vervet/African green monkey (Chlorocebus aethiops sabaeus) as a pre-clinical model to study the effects of AMA on adaptations to pregnancy. Design: Thirteen age-diverse pregnant vervet monkeys (3-16 y.o.) were utilized to measure third trimester blood pressure (BP), complete blood count, iron measure-ments and hormone levels. Results: Significant associations were observed between third trimester diastolic BP and maternal age. Furthermore, the presence of leukocytosis with enhanced circulat-ing neutrophils was observed in AMA moth...Continue Reading

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