Genetic risk of type 2 diabetes in populations of the African continent: A systematic review and meta-analyses

Diabetes Research and Clinical Practice
Y Y YakoA P Kengne

Abstract

Type 2 diabetes (T2D) is growing faster in Africa than anywhere else, driven by the dual effects of genetic and environmental factors. We conducted a systematic review and meta-analyses of published studies on genetic markers of T2D in populations within Africa. Multiple databases were searched for studies of genetic variants associated with T2D in populations living in Africa. Studies reporting on the association of a genetic marker with T2D or indicators of glycaemia were included. Data were extracted on study design and characteristics, genetic determinants, effect estimates of associations with T2D. Overall, 100 polymorphisms in 57 genes have been investigated in relation with T2D in populations within Africa, in 60 studies. Almost all studies used the candidate gene approach, with >88% published during 2006-2014 and 70% (42/60) originating from Tunisia and Egypt. Polymorphisms in ACE, AGRP, eNOS, GSTP1, HSP70-2, MC4R, MTHFR, PHLPP, POL1, TCF7L2, and TNF-α gene were found to be associated with T2D, with overlapping effect on various cardiometabolic traits. The polymorphisms investigated in multiple studies mostly had consistent effects across studies, with only modest or no statistical heterogeneity. Effect sizes were modes...Continue Reading

References

Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Feb 28, 2004·Diabetes·Charles N RotimiUNKNOWN Africa America Diabetes Mellitus (AADM) Study
Sep 1, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C BonillaR A Kittles
Jan 9, 2007·Nature Genetics·Agnar HelgasonKári Stefánsson
Apr 21, 2007·Metabolism: Clinical and Experimental·Antonel OlckersAletta E Schutte
May 4, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Stéphane CauchiPhilippe Froguel
Jun 6, 2007·Diabetes Research and Clinical Practice·Guanjie ChenCharles Rotimi
Apr 12, 2008·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Imen ArfaSonia Abdelhak
Apr 17, 2008·Journal of Diabetes and Its Complications·Intissar EzzidiWassim Y Almawi
Jul 10, 2008·Diabetes/metabolism Research and Reviews·K MakniH Ayadi
Mar 6, 2009·PLoS Medicine·Gurdeep S SagooJulian P T Higgins
Mar 17, 2009·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Thouraya BaroudiAmel Benammar-Elgaaied
Jul 9, 2010·Lancet·Jean Claude N MbanyaSostanie T Enoru
Dec 15, 2010·The New England Journal of Medicine·Mark I McCarthy
Apr 23, 2011·Genetic Testing and Molecular Biomarkers·Chamseddine KifagiHammadi Ayadi
Apr 29, 2011·Journal of Human Genetics·Sandra J HasstedtSteven C Elbein
Jun 8, 2011·Human Genetics·Mary E Travers, Mark I McCarthy
Jul 26, 2011·BMJ : British Medical Journal·Jonathan A C SterneJulian P T Higgins
Nov 8, 2011·Genetics and Molecular Research : GMR·M A AmerS H Abou-El-Ela
Oct 31, 2012·Diabetes Research and Clinical Practice·Amira TurkiWassim Y Almawi

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Citations

Jun 3, 2017·International Journal of Molecular Sciences·Ángeles OrtegaBernat Soria
Jun 6, 2017·International Journal of Epidemiology·UNKNOWN NCD Risk Factor Collaboration (NCD-RisC) – Africa Working Group
Sep 25, 2017·Environmental Health Perspectives·Maria S BornmanJerrold J Heindel
Mar 14, 2019·Journal of Diabetes·Anoop MisraKaushik L Ramaiya
Aug 19, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Karen A SchlauchVincent C Lombardi
Jul 21, 2020·Journal of Diabetes Research·Evans Adu AsamoahEnoch Odame Anto
Apr 26, 2018·Archives of Endocrinology and Metabolism·Maria Lúcia Corrêa-Giannella
Aug 5, 2021·Cell Reports·Blaz LupseAmin Ardestani

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