Genetic risk score and cardiovascular mortality in a southern european population with coronary artery disease

International Journal of Clinical Practice
Andreia PereiraRoberto Palma Dos Reis

Abstract

Several genetic risk scores (GRS) have been associated with cardiovascular disease; their role, however, in survival from proven coronary artery disease (CAD) have yielded conflicting results. The objective of this study was to evaluate long-term cardiovascular mortality according to the genetic risk score in a Southern European population with CAD. A cohort of 1464 CAD patients with angiographic proven CAD were followed up prospectively for up to 58.3 (interquartile range: 25.8-88.1) months. Genotyping of 32 single-nucleotide polymorphisms previously associated with CAD was performed using oligonucleotides probes marked with fluorescence for each allele. GRS was constructed according to the additive model assuming codominance and categorised using the median (=26). Cox Regression analysis was performed to determine independent multivariate predictors of cardiovascular mortality. Kaplan-Meier survival curves compared high vs low GRS using log-rank test. C-index was done for our population, as a measure of discrimination in survival analysis model. During a mean follow-up of 58.3 months, 156 patients (10.7%) died, 107 (7.3%) of CV causes. High GRS (≥26) was associated with reduced cardiovascular survival. Survival analysis with ...Continue Reading

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Citations

Sep 15, 2019·Current Diabetes Reports·Ayo P DoumateyCharles N Rotimi
Dec 21, 2018·Genetics and Molecular Biology·Andreia PereiraRoberto Palma Dos Reis
Sep 11, 2019·European Heart Journal·Juhani KnuutiUNKNOWN ESC Scientific Document Group
Mar 27, 2018·Current Cardiology Reports·Christopher Labos, George Thanassoulis
Nov 26, 2020·Journal of Personalized Medicine·Sergey Semaev, Elena Shakhtshneider
Jul 20, 2021·Clinical Medicine Insights. Cardiology·João Adriano SousaRoberto Palma Reis

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