Genetic risk score to predict biochemical recurrence after radical prostatectomy in prostate cancer: prospective cohort study

Oncotarget
Jong Jin OhSeok-Soo Byun

Abstract

To investigate the genetic risk score (GRS) from a large-scale exome-wide association study as a tool of prediction for biochemical recurrence (BCR) after radical prostatectomy (RP) in prostate cancer (PCa). The 16 SNPs were selected as significant predictors of BCR. The GRS in men experiencing BCR was -1.21, significantly higher than in non-BCR patients (-2.43) (p < 0.001). The 10-year BCR-free survival rate was 46.3% vs. 81.8% in the high-versus low GRS group, respectively (p < 0.001). The GRS was a significant factor after adjusting for other variables in Cox proportional hazard models (HR:1.630, p < 0.001). The predictive ability of the multivariate model without GRS was 84.4%, increased significantly to 88.0% when GRS was included (p = 0.0026). Total 912 PCa patients were enrolled who had received RP and genotype analysis using Exome chip (HumanExome BeadChip). Genetic results were obtained by the methods of logistic regression analysis which measured the odds ratio (OR) to BCR. The GRS was calculated by the sum of each weighted-risk allele count multiplied by the natural logarithm of the respective ORs. Survival analyses were performed using the GRS. We compared the accuracy of separate multivariate models incorporating c...Continue Reading

References

Dec 1, 1988·The American Journal of Surgical Pathology·J E McNealT A Stamey
May 11, 1999·JAMA : the Journal of the American Medical Association·C R PoundP C Walsh
Mar 20, 2001·American Journal of Human Genetics·M StephensP Donnelly
Jul 28, 2005·JAMA : the Journal of the American Medical Association·Stephen J FreedlandAlan W Partin
Nov 11, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Shu-Pin HuangBo-Ying Bao
Jan 18, 2011·The Journal of Urology·Scott E EggenerAndrew J Stephenson
Feb 24, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jiyoung AhnRichard B Hayes
Jun 12, 2012·Current Problems in Surgery·Supriya S PatelAnthony J Senagore
May 28, 2013·The Journal of Urology·Ian M ThompsonMartha M Faraday
Nov 12, 2013·European Urology·Axel HeidenreichUNKNOWN European Association of Urology
Sep 15, 2014·Nature Genetics·Ali Amin Al OlamaChristopher A Haiman
Oct 4, 2014·European Urology·Orestis A PanagiotouKonstantinos K Tsilidis
Jan 9, 2015·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Nora PashayanPaul D Pharoah
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Apr 4, 2015·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Ali Amin Al OlamaUNKNOWN PRACTICAL Consortium
Jul 17, 2015·The Prostate·Robert SzulkinFredrik Wiklund
Jan 26, 2016·Urology·Eric A KleinCristina Magi-Galluzzi

❮ Previous
Next ❯

Citations

Mar 30, 2019·Trends in Genetics : TIG·Danai ChasiotiAndrew J Saykin
May 5, 2021·Investigative and Clinical Urology·Sang Hun Song, Seok Soo Byun

❮ Previous
Next ❯

Methods Mentioned

BETA
chip
chips
biopsy
genotyping

Software Mentioned

SAS
Medicalc
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.