Genetic Risk Scores for Complex Disease Traits in Youth.

Circulation. Genomic and Precision Medicine
Tian XieHarold Snieder

Abstract

For most disease-related traits the magnitude of the contribution of genetic factors in adolescents remains unclear. Twenty continuous traits related to anthropometry, cardiovascular and renal function, metabolism, and inflammation were selected from the ongoing prospective Tracking Adolescents' Individual Lives Survey cohort in the Netherlands with measurements of up to 5 waves from age 11 to 22 years (n=1354, 47.6% males) and all traits available at the third wave (mean age [SD]=16.22 [0.66]). For each trait, unweighted and weighted genetic risk scores (GRSs) were generated based on significantly associated single nucleotide polymorphisms identified from literature. The variance explained by the GRSs in adolescents were estimated by linear regression after adjustment for covariates. Except for ALT (alanine transaminase), all GRSs were significantly associated with their traits. The trait variance explained by the GRSs was highest for lipoprotein[a] (39.59%) and varied between 0.09% (ALT) and 18.49% (LDL [low-density lipoprotein]) for the other traits. For most traits, the variances explained in adolescents were comparable with or slightly smaller than those in adults. Significant increases of trait levels (except ALT) and inc...Continue Reading

References

Feb 12, 2008·International Journal of Epidemiology·Martijn HuismanJohan Ormel
Mar 28, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Zhibin LiXiaoling Wang
Jul 3, 2009·Nature·UNKNOWN International Schizophrenia ConsortiumPamela Sklar
Nov 15, 2011·The Journal of Allergy and Clinical Immunology·Mark GranadaGeorge T O'Connor
Jun 16, 2012·Atherosclerosis·Bram P PrinsJingyuan Fu
Apr 13, 2013·Behavior Genetics·Jenny H D A van BeekDorret I Boomsma
Oct 8, 2013·Nature Genetics·Cristen J WillerUNKNOWN Global Lipids Genetics Consortium
Dec 10, 2013·Nucleic Acids Research·Danielle WelterHelen Parkinson
Nov 27, 2014·European Journal of Human Genetics : EJHG·Jenny H D A van BeekDorret I Boomsma
Nov 29, 2014·International Journal of Epidemiology·Albertine J OldehinkelCatharina A Hartman
May 12, 2015·Nature Genetics·Ida SurakkaUNKNOWN ENGAGE Consortium
Oct 3, 2015·American Journal of Human Genetics·Bjarni J VilhjálmssonAlkes L Price
Nov 26, 2015·Human Molecular Genetics·Janine F FelixUNKNOWN Bone Mineral Density in Childhood Study BMDCS
Mar 13, 2016·Circulation. Cardiovascular Genetics·Priyakumari Ganesh ParmarUNKNOWN Early Genetics and Lifecourse Epidemiology Consortium
May 12, 2016·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J AarestrupJ L Baker
Dec 3, 2016·Nucleic Acids Research·Jacqueline MacArthurHelen Parkinson
Apr 6, 2017·Human Molecular Genetics·Marten E van den BergPatricia B Munroe
Jul 8, 2017·American Journal of Human Genetics·Peter M VisscherJian Yang
Oct 31, 2017·Nature Genetics·Dajiang J LiuSekar Kathiresan
Sep 19, 2018·Nature Genetics·Evangelos EvangelouUNKNOWN Million Veteran Program

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Citations

Jan 5, 2021·Current Opinion in Lipidology·Mark Trinder, Liam R Brunham
Mar 12, 2021·Human Molecular Genetics·Iain S ForrestRon Do

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Methods Mentioned

BETA
genotyping

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