Genetic signatures of pre-expansion bottleneck in the Choctaw population of Oklahoma

American Journal of Physical Anthropology
Ning WangR Chakraborty

Abstract

Previous research showed that the Choctaw Indians of Oklahoma exhibit considerable linkage disequilibria (LD) in a number of regions of the genome that has allowed genetic fine mapping for potential susceptibility genes for the autoimmune connective tissue disease scleroderma, or systemic sclerosis (SSc). In principle, such enhanced background LD in the Choctaws could be caused by population bottleneck event(s) followed by recent population expansion. This investigation utilizes genome-scan data on 175 dinucleotide loci from 76 Choctaw individuals to seek genetic evidence of the demographic history of the Choctaw Nation. Of the 175 loci examined, 105 are in Hardy-Weinberg equilibrium. The average unbiased homozygosity over the 105 loci for the Choctaws (29.3%) is significantly higher than that in the European descent group (20.9%); and when adjusted for sample-size differences, the Choctaw also exhibit a significantly smaller number of segregating alleles (6.65 vs. 8.14) at these loci. Both of these observations are consistent with the trend expected in an isolated population. Comparison of the allele size variance and gene diversity yields an imbalance index (lnbeta) of 0.811 in the Choctaw. Of the 105 loci examined, 93 exhibi...Continue Reading

References

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Citations

Dec 7, 2011·Proceedings of the National Academy of Sciences of the United States of America·Brendan D O'Fallon, Lars Fehren-Schmitz
Jul 12, 2008·American Journal of Physical Anthropology·Melissa S Halverson, Deborah A Bolnick
Dec 9, 2020·American Journal of Human Biology : the Official Journal of the Human Biology Council·Tara J Cepon-Robins

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