Genetic Similarity Assessment of Twin-Family Populations by Custom-Designed Genotyping Array

Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies
Jeffrey J BeckGareth E Davies

Abstract

Twin registries often take part in large collaborative projects and are major contributors to genome-wide association (GWA) meta-analysis studies. In this article, we describe genotyping of twin-family populations from Australia, the Midwestern USA (Avera Twin Register), the Netherlands (Netherlands Twin Register), as well as a sample of mothers of twins from Nigeria to assess the extent, if any, of genetic differences between them. Genotyping in all cohorts was done using a custom-designed Illumina Global Screening Array (GSA), optimized to improve imputation quality for population-specific GWA studies. We investigated the degree of genetic similarity between the populations using several measures of population variation with genotype data generated from the GSA. Visualization of principal component analysis (PCA) revealed that the Australian, Dutch and Midwestern American populations exhibit negligible interpopulation stratification when compared to each other, to a reference European population and to globally distant populations. Estimations of fixation indices (FST values) between the Australian, Midwestern American and Netherlands populations suggest minimal genetic differentiation compared to the estimates between each p...Continue Reading

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Citations

Dec 5, 2019·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Yoon-Mi HurTimothy Bates
Oct 15, 2019·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Julie M KittelsrudGareth E Davies
Jul 22, 2021·Human Genomics·John L SluneckaErik A Ehli
Aug 15, 2021·Behavior Genetics·Camiel M van der LaanDorret I Boomsma

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