Genetic structure adds power to detect schizophrenia susceptibility at SLIT3 in the Chinese Han population

Genome Research
Yongyong ShiLin He


The Chinese Han population, the largest population in the world, has traditionally been geographically divided into two parts, the Southern Han and Northern Han. In practice, however, these commonly used ethnic labels are both insufficient and inaccurate as descriptors of inferred genetic clustering, and can lead to the observation of "spurious association" as well as the concealment of real association. In this study, we attempted to address this problem by using 14 microsatellite markers to reconstruct the population genetic structure in 768 Han Chinese samples, including 384 Southern Han and 384 Northern Han, and in samples from Chinese minorities including 48 Yao and 48 BouYei subjects. Furthermore, with a dense set of markers around the region 5q34-35, we built fine-scale haplotype networks for each population/subpopulation and tested for association to schizophrenia susceptibility. We found that more variants in SLIT3 tend to associate with schizophrenia susceptibility in the genetically structured samples, compared to geographically structured samples and samples without identified population substructure. Our results imply that identifying the hidden genetic substructure adds power when detecting association, and sugges...Continue Reading


Jul 1, 1995·Annals of Human Genetics·P C Sham, D Curtis
Sep 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·J Y ChuL Jin
May 29, 2000·American Journal of Human Genetics·J K PritchardP Donnelly
Nov 30, 2000·Proceedings of the National Academy of Sciences of the United States of America·Y C DingY Zhang
Mar 20, 2001·Nature Reviews. Genetics·L Jin, B Su
Mar 20, 2001·American Journal of Human Genetics·M StephensP Donnelly
Jul 27, 2001·Mechanisms of Development·N VargessonE Laufer
Jan 5, 2002·Journal of Physiology, Paris·Kim T Nguyen-Ba-Charvet, Alain Chédotal
May 16, 2002·American Journal of Physical Anthropology·Hiroki OotaMark Stoneking
Sep 17, 2002·Molecular Psychiatry·E J C G van den Oord
Apr 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Wenlin YuanDavid M Ornitz

❮ Previous
Next ❯


Jan 13, 2006·Molecular Psychiatry·R Q TangL He
Feb 6, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Yuyu XiongShengying Qin
Apr 24, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·C FangY Y Shi
Jul 7, 2009·Neuroscience Letters·Chen ZhangShunying Yu
Oct 31, 2012·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Aihua YuanShunying Yu
Aug 25, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Hong PengJin-Jun Guo
Jul 31, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jianhua XuJing Du
Sep 28, 2004·American Journal of Human Genetics·Qi ChenLin He
Oct 13, 2006·Human Molecular Genetics·Xiangning ChenKenneth S Kendler
Nov 30, 2018·Frontiers in Behavioral Neuroscience·Su Mi ParkShiyong Huang

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.