Genetic structure of Anopheles gambiae populations on islands in northwestern Lake Victoria, Uganda

Malaria Journal
J K KayondoFrank H Collins

Abstract

Alternative means of malaria control are urgently needed. Evaluating the effectiveness of measures that involve genetic manipulation of vector populations will be facilitated by identifying small, genetically isolated vector populations. The study was designed to use variation in microsatellite markers to look at genetic structure across four Lake Victoria islands and two surrounding mainland populations and for evidence of any restriction to free gene flow. Four Islands (from 20-50 km apart) and two surrounding mainland populations (96 km apart) were studied. Samples of indoor resting adult mosquitoes, collected over two consecutive years, were genotyped at microsatellite loci distributed broadly throughout the genome and analysed for genetic structure, effective migration (Nem) and effective population size (Ne). Ne estimates showed island populations to consist of smaller demes compared to the mainland ones. Most populations were significantly differentiated geographically, and from one year to the other. Average geographic pair-wise FST ranged from 0.014-0.105 and several pairs of populations had Ne m < 3. The loci showed broad heterogeneity at capturing or estimating population differences. These island populations are sig...Continue Reading

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Related Concepts

Human Geography
Insect Vectors
Chromosome Inversion
Genetic Polymorphism
Underpopulation
Variation (Genetics)
Log-Linear Models
Nested Polymerase Chain Reaction
Tetranucleotide Repeats
Anopheles gambiae

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