PMID: 8599055Jul 1, 1995Paper

Genetic structure of Neisseria meningitidis serogroup C epidemic strains in south Brazil

Revista Do Instituto De Medicina Tropical De São Paulo
C T SacchiA Sperb

Abstract

In the present study we report the results of an analysis, based on serotyping, multilocus enzyme electrophoresis (MEE), and ribotyping of N. meningitidis serogroup C strains isolated from patients with meningococcal disease (MD) in Rio Grande do Sul (RS) and Santa Catarina (SC) States, Brazil, as the Center of Epidemiology Control of Ministry of Health detected an increasing of MD cases due to this serogroup in the last two years (1992-1993). We have demonstrated that the MD due to N.meningitidis serogroup C strains in RS and SC States occurring in the last 4 years were caused mainly by one clone of strains (ET 40), with isolates indistinguishable by serogroup, serotype, subtype and even by ribotyping. One small number of cases that were not due to an ET 40 strains, represent closely related clones that probably are new lineages generated from the ET 40 clone referred as ET 11A complex. We have also analyzed N.meningitidis serogroup C strains isolated in the greater São Paulo in 1976 as representative of the first post epidemic year in that region. The ribotyping method, as well as MEE, could provide useful information about the clonal characteristics of those isolates and also of strains isolated in south Brazil. The strains ...Continue Reading

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Citations

Oct 2, 1998·Revista Do Instituto De Medicina Tropical De São Paulo·C T SacchiL W Mayer
Jul 14, 2001·Revista Do Instituto De Medicina Tropical De São Paulo·A P LemosL W Mayer

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