Genetic structure of phenotypic robustness in the collaborative cross mouse diallel panel

Journal of Evolutionary Biology
Paula N GonzalezBenedikt Hallgrímsson

Abstract

Developmental stability and canalization describe the ability of developmental systems to minimize phenotypic variation in the face of stochastic micro-environmental effects, genetic variation and environmental influences. Canalization is the ability to minimize the effects of genetic or environmental effects, whereas developmental stability is the ability to minimize the effects of micro-environmental effects within individuals. Despite much attention, the mechanisms that underlie these two components of phenotypic robustness remain unknown. We investigated the genetic structure of phenotypic robustness in the collaborative cross (CC) mouse reference population. We analysed the magnitude of fluctuating asymmetry (FA) and among-individual variation of cranial shape in reciprocal crosses among the eight parental strains, using geometric morphometrics and a diallel analysis based on a Bayesian approach. Significant differences among genotypes were found for both measures, although they were poorly correlated at the level of individuals. An overall positive effect of inbreeding was found for both components of variation. The strain CAST/EiJ exerted a positive additive effect on FA and, to a lesser extent, among-individual variance...Continue Reading

Associated Datasets

May 30, 2016·Benedikt HallgrimssonFernando Pardo-Manuel De Villena

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Citations

Jan 18, 2017·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Mihaela PavličevBenedikt Hallgrimsson
Mar 3, 2019·Biomedicines·Panagiota Giardoglou, Dimitris Beis
Sep 14, 2018·Heredity·Ceferino Varón-González, Nicolas Navarro
Feb 28, 2019·Frontiers in Genetics·Ceferino Varón-GonzálezNicolas Navarro
Dec 14, 2018·Frontiers in Genetics·Jennifer LachowiecChristine Queitsch
Sep 30, 2017·PLoS Genetics·Anlu ChenDavid A Buchner
Nov 6, 2018·G3 : Genes - Genomes - Genetics·Robert W Corty, William Valdar

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