Nov 1, 1983

Genetic studies in ankylosing spondylitis

British Journal of Rheumatology
J C WoodrowG H Whitehouse

Abstract

It is likely that ankylosing spondylitis is genetically heterogeneous. The evidence favours the gene for HLA-B27 being the major genetic factor responsible for susceptibility. The finding of a greater prevalence of disease in B27 positive first-degree male relatives of probands than in random B27 positive controls, suggests the existence of other genes for susceptibility, possibly HLA-linked.

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Mentioned in this Paper

Genetics, Population
HLA Antigens
HLA-B27 Antigen
HLA Class I Histocompatibility Antigen, B-27 alpha Chain
Ankylosing Spondylitis
Human Leukocyte Antigen B27 (Lab Test)

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