PMID: 6413385Jan 1, 1983Paper

Genetic studies of an apoA-I lipoprotein variant

Human Genetics
O SchamaunP Teisberg

Abstract

ApoA-I is the major apolipoprotein component of human high density lipoproteins (HDL). By a 2-D electrophoretic study of serum samples from Norwegian families, an apoA-I variant (apoA-I 2-1) was detected in a healthy individual. In the present study performed to elucidate formal and population genetic aspects of apoA-I, this variant was observed in 4 generations of the family of the propositus. One homozygous individual was found. A codominant autosomal Mendelian inheritance was established for the variant. Two heterozygotes were found among 124 unrelated individuals tested. The apoA-I 2 allele frequency was calculated as 0.008 in this population sample.

References

Nov 1, 1977·The Journal of Clinical Investigation·G AssmannE Smootz
Feb 14, 1978·Biochemical and Biophysical Research Communications·H B BrewerT J Bronzert
Feb 25, 1972·Biochemical and Biophysical Research Communications·C J FieldingP E Fielding
Apr 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·L L KayH B Brewer

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