Genetic studies of human apolipoproteins: XII. Population genetics of apolipoproteins in Papua New Guinea

American Journal of Human Biology : the Official Journal of the Human Biology Council
M I KambohR E Ferrell

Abstract

The gene products of the apolipoprotein A-I, A-II, A-IV, C-II, C-III, D, E and H loci have been screened by isoelectric focusing followed by immunoblotting from two Papua New Guinean populations, the Huli and the Pawaia. Only APO E and APO H revealed common polymorphisms. A putative unique A-IV variant has been identified, but due to the lack of family data it is not characterized further. Three common APO H alleles were observed in both groups with comparable frequencies. But significantly different distributions of three APO E alleles were noted in the Huli and the Pawaia. The respective frequencies of the APO E*2, APO E*3, and APO E*4 alleles were 0.154, 0.356, and 0.490 in the Huli and 0.138, 0.603, and 0.259 in the Pawaia. A strikingly high frequency of the APO E*4 allele in Papua New Guinea may provide a useful insight into the studies of genetic and environmental interactions in controlling the cholesterol levels in the general population.

References

Jan 1, 1988·Physiological Reviews·J L Breslow
Jan 1, 1988·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·J DavignonC F Sing
Oct 1, 1986·Australian Veterinary Journal·A N Hamir
Jan 28, 1967·The Medical Journal of Australia·J Kariks, V J McGovern
Jun 27, 1964·The Medical Journal of Australia·C H CAMPBELL, R K ARTHUR

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Citations

Sep 5, 2001·American Journal of Human Biology : the Official Journal of the Human Biology Council·R.M. CorboG.F. De Stefano
Jan 1, 1994·American Journal of Human Biology : the Official Journal of the Human Biology Council·William S Pollitzer
Sep 15, 1994·American Journal of Medical Genetics·M Rutter
Aug 24, 2005·British Journal of Haematology·Heidi Rye HudlebuschThomas Rasmussen
Nov 10, 2006·Annals of Human Biology·P P SinghS S Mastana
Jan 1, 1994·The American Journal of Drug and Alcohol Abuse·J L KleinM A Schuckit
Jul 1, 1994·Journal of Biosocial Science·R Ohtsuka
Mar 1, 1992·Medical Anthropology·P K Townsend, A McElroy
Jan 1, 1994·Asia-Pacific Journal of Public Health·T HongoT Suzuki
Mar 26, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D A Merriwether
Dec 13, 2006·American Journal of Human Biology : the Official Journal of the Human Biology Council·Huan ZhouRyutaro Ohtsuka
Sep 15, 2001·Applied Immunohistochemistry & Molecular Morphology : AIMM·C R Taylor, C R Riley
Oct 7, 2011·American Journal of Reproductive Immunology : AJRI·Jitka RynekrovaJaroslav A Hubacek
Mar 24, 2005·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Said Ali S Al-YahyaeeAli Hassan Al-Bahrani
Aug 19, 2011·Biodemography and Social Biology·Sarinnapha VasunilashornHooman Allayee

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