Genetic study links components of the autonomous nervous system to heart-rate profile during exercise

Nature Communications
Niek VerweijPim van der Harst

Abstract

Heart rate (HR) responds to exercise by increasing during exercise and recovering after exercise. As such, HR is an important predictor of mortality that researchers believe is modulated by the autonomic nervous system. However, the mechanistic basis underlying inter-individual differences has yet to be explained. Here, we perform a large-scale genome-wide analysis of HR increase and HR recovery in 58,818 UK Biobank individuals. Twenty-five independent SNPs in 23 loci are identified to be associated (p < 8.3 × 10-9) with HR increase or HR recovery. A total of 36 candidate causal genes are prioritized that are enriched for pathways related to neuron biology. No evidence is found of a causal relationship with mortality or cardiovascular diseases. However, a nominal association with parental lifespan requires further study. In conclusion, the findings provide new biological and clinical insight into the mechanistic underpinnings of HR response to exercise. The results also underscore the role of the autonomous nervous system in HR recovery.

Associated Datasets

Feb 20, 2018·Niek Verweij, Niek Verweij

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Citations

Dec 13, 2018·Physiology·Alexander V Gourine, Gareth L Ackland
Mar 10, 2020·Circulation·Mateusz SiedlinskiTomasz J Guzik
Mar 29, 2019·Cellular and Molecular Life Sciences : CMLS·Yordi J van de VegtePim van der Harst
May 7, 2020·The Journal of Clinical Endocrinology and Metabolism·Eirini MarouliMarco Medici
Jul 17, 2020·ELife·Jan Hendrik van WeerdVincent M Christoffels
Apr 23, 2020·Nature Communications·Yordi J van de VegteNiek Verweij
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Jul 3, 2021·JRSM Cardiovascular Disease·Julia RamírezAndrew Tinker
Oct 31, 2021·Development, Growth & Differentiation·Pengcheng Ma, Bingyu Mao

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Methods Mentioned

BETA
Hi-C
genotyping
chip

Software Mentioned

HUGin
plink
PhenoScanner
Cardiosoft
SE
R
DEPICT
STATA
package forecast
LMM

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