Genetic study of capsular switching between Neisseria meningitidis sequence type 7 serogroup A and C strains.

Infection and Immunity
Quan WangLei Wang

Abstract

Neisseria meningitidis is a leading cause of septicemia and meningitis worldwide. N. meningitidis capsular polysaccharides have been classified into 13 distinct serogroups which are defined by antibody reactivity and structural analysis, and the capsule plays an important role in virulence. Serogroups A, B, C, W135, and Y have been reported to be clinically important. Several newly identified serogroup C isolates belonging to the unique sequence type 7 (ST-7) were identified in China. Since most ST-7 isolates from China belonged to serogroup A, the newly identified ST-7 serogroup C strains were proposed to have arisen from those belonging to ST-7 serogroup A. In this study, six ST-7 serogroup C and three ST-7 serogroup A isolates were analyzed by pulsed-field gel electrophoresis to confirm their sequence type. In order to clarify the genetic basis of capsular switching between ST-7 serogroup A and C strains, the whole capsular gene clusters and surrounding genes of the two representative ST-7 strains belonging to serogroups A and C, respectively, were sequenced and compared. Potential recombination sites were analyzed using the RDP3 beta software, and recombination-related regions in two other ST-7 serogroup A and five ST-7 ser...Continue Reading

References

Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S D Goodman, J J Scocca
Jan 1, 1983·Reviews of Infectious Diseases·H Peltola
Jan 7, 1997·Proceedings of the National Academy of Sciences of the United States of America·J S SwartleyD S Stephens
May 3, 2001·The New England Journal of Medicine·N E RosensteinJ M Hughes
Sep 15, 2006·Journal of Virology·Livio HeathDarren P Martin
Sep 14, 2007·Scandinavian Journal of Infectious Diseases·Junping PengQi Jin
May 28, 2008·The Journal of Experimental Medicine·Maria Jose UriaChristoph M Tang
May 20, 2009·Infection and Immunity·Amanda J BeddekDiana R Martin
Jan 1, 2009·Genome Biology and Evolution·W A Findlay, R J Redfield

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Citations

Nov 16, 2011·Genome Biology and Evolution·Weilong HaoDavid C Alexander
Aug 21, 2012·Journal of Bacteriology·Lavanya RishishwarI King Jordan
Aug 2, 2014·Journal of Medical Microbiology·Bingqing ZhuZhujun Shao
Jul 15, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Zheng XuZhujun Shao
Jun 20, 2015·Critical Reviews in Microbiology·Yih-Ling TzengDavid S Stephens
May 20, 2015·Emerging Infectious Diseases·Bingqing ZhuZhujun Shao
Apr 7, 2018·Infectious Diseases·Luciete A SilvaDavid E Barroso

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