Abstract
The phenomenon of zonal resistance to lincomycin, which is characteristic of most clinical isolates with lincomycin resistance in Streptococcus pyogenes, has been studied. These strains grow within a defined concentration range of lincomycin (approximately 60 to 200 microgram/ml), or at lincomycin concentrations below the minimal inhibitory concentration for susceptible strains. It is shown that the zonal growth phenomenon is a stable phenotype and results from induction of resistance only within the zonal concentration range of lincomycin. These strains also possess inducible resistance to erythromycin which is nonzonal in character. One-step mutations to constitutive resistance have been isolated which are of two types: constitutive for lincomycin or for erythromycin, but not for both. Those strains with constitutive erythromycin resistance retain their zonal resistance for lincomycin. Mutants doubly constitutive for both lincomycin and erythromycin can be obtained by a second mutational step from either of the singly constitutive mutants. Satellite deoxyribonucleic acid has been shown to be present in the zonal resistant strains. A plasmid, pSM10419, of 14.9 megadaltons, has been isolated from one of the doubly constitutive ...Continue Reading
References
Dec 1, 1976·Analytical Biochemistry·T C Currier, E W Nester
Oct 1, 1979·Plasmid·D BehnkeF Walter
Jan 1, 1977·Gene·F BolivarS Falkow
Aug 1, 1978·Nucleic Acids Research·J G Sutcliffe
Jan 1, 1979·Plasmid·V Hershfield
Jul 1, 1978·Nucleic Acids Research·P J GreeneH W Boyer
Mar 30, 1976·Molecular & General Genetics : MGG·H MalkeK Störl
Apr 1, 1977·Antimicrobial Agents and Chemotherapy·N E Allen
Nov 5, 1975·Journal of Molecular Biology·K Murray, N E Murray
Sep 1, 1975·Analytical Biochemistry·B SugdenJ Sambrook
Jan 1, 1974·Molecular & General Genetics : MGG·P M CourvalinD Blangy
Dec 4, 1973·Biochemistry·A PanetK Kleppe
Dec 1, 1970·Journal of General Microbiology·A L BakA Stenderup
May 1, 1974·Antimicrobial Agents and Chemotherapy·T Tanaka, B Weisblum
Sep 1, 1973·Antimicrobial Agents and Chemotherapy·S L Hyder, M M Streitfeld
Sep 12, 1973·Molecular & General Genetics : MGG·H Malke
Apr 1, 1972·Antimicrobial Agents and Chemotherapy·J M Dixon, A E Lipinski
Oct 1, 1974·The Journal of Infectious Diseases·J M Dixon, A E Lipinski
May 1, 1974·Antimicrobial Agents and Chemotherapy·D B Clewell, A E Franke
Jan 1, 1974·Molecular & General Genetics : MGG·H Malke
Oct 1, 1968·Biochemistry·M Bazaral, D R Helinski
Citations
Jan 1, 1981·Molecular & General Genetics : MGG·H MalkeS E Holm
Jan 1, 1981·Molecular & General Genetics : MGG·D Behnke
Jan 1, 1982·Molecular & General Genetics : MGG·V I GolubkovA A Totolian
Jan 1, 1982·Molecular & General Genetics : MGG·H MalkeS E Holm
Jan 1, 1984·Molecular & General Genetics : MGG·M Israeli-RechesD Dubnau
Sep 17, 1998·The Journal of Antimicrobial Chemotherapy·N Barg
Mar 1, 1992·Antimicrobial Agents and Chemotherapy·M ReigF Baquero
Jan 22, 2014·International Journal of Medical Microbiology : IJMM·René BergmannD Patric Nitsche-Schmitz
Jan 1, 1988·Journal of Basic Microbiology·F LaplaceH Malke
Jul 1, 1997·Equine Veterinary Journal·A GustafssonA Franklin
Jul 1, 1997·Equine Veterinary Journal·V BåverudA Gunnarsson
Jul 1, 1986·Equine Veterinary Journal·R H Whitlock
Nov 1, 1988·Equine Veterinary Journal·J F PrescottK Delaney
Jul 12, 2012·Equine Veterinary Journal·B S BarrD J Weigel
Mar 24, 2020·The Veterinary Record·Motoi NomuraHidekazu Niwa
Jan 1, 1981·Molecular & General Genetics : MGG·H Malke, S E Holm
Jan 1, 1984·Zeitschrift für allgemeine Mikrobiologie·I RiemeltH Malke
Aug 1, 1993·Journal of Chemotherapy·I Barcs
Apr 4, 1998·Antimicrobial Agents and Chemotherapy·H SeppäläP Huovinen
Dec 31, 1998·Antimicrobial Agents and Chemotherapy·J KatajaH Seppälä
May 1, 1982·Applied and Environmental Microbiology·J K Kondo, L L McKay