Genetic subdivision and candidate genes under selection in North American grey wolves

Molecular Ecology
Rena M SchweizerRobert K Wayne

Abstract

Previous genetic studies of the highly mobile grey wolf (Canis lupus) found population structure that coincides with habitat and phenotype differences. We hypothesized that these ecologically distinct populations (ecotypes) should exhibit signatures of selection in genes related to morphology, coat colour and metabolism. To test these predictions, we quantified population structure related to habitat using a genotyping array to assess variation in 42 036 single-nucleotide polymorphisms (SNPs) in 111 North American grey wolves. Using these SNP data and individual-level measurements of 12 environmental variables, we identified six ecotypes: West Forest, Boreal Forest, Arctic, High Arctic, British Columbia and Atlantic Forest. Next, we explored signals of selection across these wolf ecotypes through the use of three complementary methods to detect selection: FST /haplotype homozygosity bivariate percentilae, bayescan, and environmentally correlated directional selection with bayenv. Across all methods, we found consistent signals of selection on genes related to morphology, coat coloration, metabolism, as predicted, as well as vision and hearing. In several high-ranking candidate genes, including LEPR, TYR and SLC14A2, we found va...Continue Reading

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Citations

Apr 22, 2016·Nucleic Acids Research·Jüri ReimandJaak Vilo
Apr 12, 2016·Molecular Ecology·Robert K Wayne, H Bradley Shaffer
Jul 1, 2017·Molecular Ecology·Flavia Termignoni-GarcíaPatricia Escalante-Pliego
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Apr 24, 2016·Molecular Ecology·Bridgett M vonHoldtRobert K Wayne
Jun 24, 2021·Molecular Ecology·Ulrike H TaronJennifer A Leonard
Jul 31, 2021·ELife·Joseph MarcusJohn Novembre

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