Genetic subgroup of small ruminant lentiviruses that infects sheep homozygous for TMEM154 frameshift deletion mutation A4Δ53

Veterinary Research
Michael L ClawsonKreg A Leymaster

Abstract

Small ruminant lentivirus (SRLV) infections of sheep are influenced by genetics on both the host and pathogen sides. Genetic variation in the ovine transmembrane 154 (TMEM154) gene associates with infection susceptibility, and distinct SRLV genetic subgroups infect sheep in association with their TMEM154 diplotypes. In this study, a novel SRLV subgroup was identified that naturally infected sheep with various TMEM154 diplotypes, including those homozygous for a rare frameshift mutation (A4 delta53), which is predicted to abolish TMEM154 protein function. Thus, these SRLVs may infect sheep that lack functional TMEM154, and may not be restricted by TMEM154 diplotypes in establishing infections.

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Jul 31, 2013·Veterinary Research·Lucia H SiderMichael L Clawson

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Citations

Dec 12, 2018·Microbiology Resource Announcements·Aspen M WorkmanAaron M Dickey
Feb 6, 2021·The Veterinary Clinics of North America. Food Animal Practice·Cindy Wolf

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Datasets Mentioned

BETA
KP120539

Methods Mentioned

BETA
enzyme linked immunosorbent assay
PCR

Software Mentioned

Dnadist
Consense
ClustalW
Dendroscope
MacVector
Consed
Phred
Seqboot
Polyphred
Phrap

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