PMID: 9420238Jan 7, 1998Paper

Genetic subtype-independent inhibition of human immunodeficiency virus type 1 replication by CC and CXC chemokines

Journal of Virology
A TrkolaJ P Moore

Abstract

We have studied the breadth and potency of the inhibitory actions of the CC chemokines macrophage inhibitory protein 1alpha (MIP-1alpha), MIP-1beta, and RANTES against macrophage-tropic (M-tropic) primary isolates of human immunodeficiency virus type 1 (HIV-1) and of the CXC chemokine stromal cell-derived factor 1alpha against T-cell-tropic (T-tropic) isolates, using mitogen-stimulated primary CD4+ T cells as targets. There was considerable interisolate variation in the sensitivity of HIV-1 to chemokine inhibition, which was especially pronounced for the CC chemokines and M-tropic strains. However, this variation was not obviously dependent on the genetic subtype (A through F) of the virus isolates. Peripheral blood mononuclear cell donor-dependent variation in chemokine inhibition potency was also observed. Among the CC chemokines, the rank order for potency (from most to least potent) was RANTES, MIP-1beta, MIP-1alpha. Some M-tropic isolates, unexpectedly, were much more sensitive to RANTES than to MIP-1beta, whereas other isolates showed sensitivities comparable to those of these two chemokines. Down-regulation of the CCR5 and CXCR4 receptors occurred in cells treated with the cognate chemokines and probably contributes to a...Continue Reading

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Citations

Jun 8, 1999·Annual Review of Immunology·E A BergerJ M Farber
Jul 11, 2000·The Journal of Biological Chemistry·T MiyagiR Y Chuang
Jul 13, 2005·Chemical Communications : Chem Comm·Suk-Yu WongChi-Ming Che
Oct 13, 2005·Chemical Communications : Chem Comm·Raymond Wai-Yin SunChi-Ming Che
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Apr 12, 2003·AIDS Research and Human Retroviruses·Thomas J KetasJohn P Moore
Sep 10, 2003·Journal of Leukocyte Biology·Eleanore GrossHelena Schmidtmayerova
Jul 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ping AnCheryl A Winkler
Jan 24, 2002·AIDS Research and Human Retroviruses·Denis M TebitOttmar Herchenröder
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May 3, 2007·Cytometry. Part B, Clinical Cytometry·Priscilla BiswasGiuseppe Tambussi
Nov 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Hubert GaertnerOliver Hartley
Apr 30, 2015·PloS One·Claudia BönschOliver Hartley
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Jan 10, 2002·Proceedings of the National Academy of Sciences of the United States of America·Alexandra TrkolaJohn P Moore
May 1, 2010·Viruses·Michael A LobritzEric J Arts
Nov 3, 2010·The Journal of Biological Chemistry·Jean-Michel EscolaOliver Hartley

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