Genetic subtypes of human immunodeficiency virus type 1 (HIV-1) in Istanbul, Turkey

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
Gülden YilmazKemal Altaş

Abstract

Epidemiological surveillance of HIV-1 subtypes is an important and ongoing element of preparation for global antiviral interventions. To assess the molecular epidemiology of HIV-1 in Istanbul, Turkey. 27 HIV/AIDS patients were investigated. Data on age, sex, country of birth, and HIV acquisition route were collected. Following amplification with PCR the sequences of the gp41 region of the env gene were determined using a 310 DNA sequencer (ABI prism, Foster City, USA) and phylogenetically analyzed. Among the 27 patients (26 adults and 1 infant), 22 were male, born in Turkey, and 20 infected through heterosexual contact. Two patients acquired the virus through blood and/or blood transfusion and one infant by vertical transmission. The distribution of the subtypes was as follows: four were subtype A, 19 subtype B, one subtype C, one subtype D, and two subtype F1. According to our results, although the B subtype is still predominant, non-B subtypes are also present, even though the number of registered HIV/AIDS patients is low. These are the first subtyped HIV-1 strains in Turkey where a low level of HIV prevalence has been observed since the first reported case in 1985. These findings and Turkey's specific geographic localization...Continue Reading

References

Nov 25, 2003·Hematology·Paul A VolberdingAlexandra M Levine
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Citations

Jan 9, 2013·Medical Microbiology and Immunology·Dilek AlpsarBaki Akgül
Feb 3, 2009·AIDS Research and Human Retroviruses·Zahra Soheila SoheilliShahram Samiei
Nov 16, 2006·BMC Infectious Diseases·Saeed KhanSyed H Ali
Feb 18, 2010·HIV Therapy·Philip A Chan, Rami Kantor
Nov 15, 2014·Journal of the International AIDS Society·Dilara Inan, Murat Sayan

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