Genetic Susceptibility for Cervical Cancer in African Populations: What Are the Host Genetic Drivers?

Omics : a Journal of Integrative Biology
Oppah KuguyoCollet Dandara

Abstract

Human papillomavirus (HPV) is an essential but not a sufficient cervical cancer etiological factor. Cancer promoters, such as host genetic mutations, significantly modulate therapeutic responses and susceptibility. In cervical cancer, of interest have been viral clearing genes and HPV oncoprotein targets, for which conflicting data have been reported among different populations. This expert analysis evaluates cervical cancer genetic susceptibility biomarkers studied in African populations. Notably, the past decade has seen Africa as a hotbed of biomarker and precision medicine innovations, thus potentially informing worldwide biomarker development strategies. We conducted a critical literature search in PubMed/MEDLINE, Google Scholar, and Scopus databases for case-control studies reporting on cervical cancer genetic polymorphisms among Africans. We found that seven African countries conducted cervical cancer molecular epidemiology studies in one of Casp8, p53, CCR2, FASL, HLA, IL10, TGF-beta, and TNF-alpha genes. This analysis reveals a remarkable gap in cervical cancer molecular epidemiology among Africans, whereas cervical cancer continues to disproportionately have an impact on African populations. Genome-wide association, w...Continue Reading

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Citations

Aug 4, 2020·OTO Open : the Official Open Access Journal of the American Academy of Otolaryngology--Head and Neck Surgery Foundation·Eyituoyo OkoturoTaofiq Opaleye
Jun 27, 2019·Cells·Patti OlusolaSantanu Dasgupta
Dec 30, 2020·Current Opinion in Genetics & Development·Nchangwi S MunungPontsho Moela
Nov 7, 2021·Journal of Racial and Ethnic Health Disparities·Sanchita ChandraParamita Mandal

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