Genetic susceptibility in obsessive-compulsive disorder

Handbook of Clinical Neurology
Thomas V FernandezChristopher Pittenger

Abstract

Obsessive-compulsive disorder (OCD) is present in 1.5-2.5% of the population and can result in substantial lifelong disability. It is characterized by intrusive thoughts, sensations, and urges and by repetitive behaviors that are difficult to control despite, in most cases, preserved insight as to their excessive or irrational nature. The causes and underlying pathophysiology of OCD are not well understood, which has limited the development of new treatments and interventions. Despite evidence for a substantial genetic contribution to disease risk, identification and replication of genetic variants associated with OCD have been challenging. Decades of candidate gene association studies have provided little insight. They are now being supplanted by modern genomewide approaches to discover both common and rare sequence and structural variants. Studies to date suggest potential novel therapeutic avenues such as modulators of glutamatergic and immune pathways; however, individual genetic findings are not yet statistically robust or replicated. Further efforts are clearly needed to identify specific risk variants and to confirm vulnerable pathways by studying much larger cohorts of patients with comprehensive variant discovery appro...Continue Reading

Citations

Jun 17, 2020·The American Journal of Psychiatry·Jian XuChristopher Pittenger
Aug 12, 2018·Brain Sciences·Hugues LamotheLuc Mallet
Jan 2, 2021·The American Journal of Psychiatry·Wayne K GoodmanSameer A Sheth

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Related Papers

European Child & Adolescent Psychiatry
Susanne WalitzaKlaus W Lange
Best Practice & Research. Clinical Gastroenterology
Nicholas M Plugis, Chaitan Khosla
© 2022 Meta ULC. All rights reserved