Genetic susceptibility of myocardial infarction

Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies
S ZdravkovicU de Faire

Abstract

The aim of this study was to determine the influence of genetic factors on the first episode of acute myocardial infarction. Probandwise concordances, tetrachoric correlations and quantitative genetic analyses of liability were applied to data drawn from the Swedish Twin Registry and the Swedish Acute Myocardial Infarction Register. All same-sexed twin pairs born between 1886 and 1958 who were alive in 1987 were included in the analyses. Our results show that concordance rates for acute myocardial infarction in monozygotic (MZ) twins were similar across sexes (among males .26 and females .27). For dizygotic (DZ) twins the concordances were .20 for males and .16 for females, yielding a greater MZ-DZ concordance differential for females than males. Tetrachoric correlations were greater for MZ than DZ twins for both sexes (.49 for male MZ and .34 for male DZ-twins and .56 and .35 for female MZ and DZ twins respectively). Quantitative genetic analyses of liability resulted in equal variance components for males and females (.36) but significantly different thresholds (prevalences). In conclusion, liability to first occurrence of acute myocardial infarction is moderately influenced by genetic variants in both sexes. The familial inf...Continue Reading

References

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Citations

Aug 31, 2012·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Pia SvedbergJurgita Narusyte
Jul 31, 2008·BMC Public Health·Sean A MartinUNKNOWN Florey Adelaide Male Ageing Study (FAMAS)
Oct 20, 2012·Genome Biology·Jordana T Bell, Tim D Spector
Feb 26, 2010·Genome Medicine·Naomi R Wray, Michael E Goddard
Dec 9, 2014·Genome Medicine·Juan E Castillo-FernandezJordana T Bell
Dec 24, 2008·Biological Psychiatry·Kenneth S KendlerMargaret Gatz
Apr 4, 2019·Human Genetics·Elisabeth DahlqwistArvid Sjölander
Mar 25, 2017·International Journal of Epidemiology·Karri SilventoinenJaakko Kaprio

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