Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions

Pharmacogenetics and Genomics
Shuen-Iu HungYuan-Tsong Chen

Abstract

The anticonvulsant carbamazepine (CBZ) frequently causes cutaneous adverse drug reactions (cADRs), including maculopapular eruption (MPE), hypersensitivity syndrome (HSS), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). We reported that SJS/TEN caused by CBZ is strongly associated with the HLA-B*1502 gene in Han Chinese. Here, we extended our genetic study to different types of CBZ-cADRs (91 patients, including 60 patients with SJS/TEN, 13 patients with hypersensitivity syndrome and 18 with maculopapular exanthema versus 144 tolerant controls). We used MALDI-TOF mass spectrometry to screen the genetic association of 278 single nucleotide polymorphisms (SNPs), which cover the major histocompatibility complex (MHC) region, tumor necrosis factor-alpha, heat shock protein and CBZ-metabolic enzymes, including CYP3A4, 2B6, 2C8, 2C9, 1A2 and epoxide hydrolase 1. In addition, we genotyped 20 microsatellites in the MHC region and performed HLA-typing to construct the recombinant map. We narrowed the susceptibility locus for CBZ-SJS/TEN to within 86 kb flanking the HLA-B gene on the extended B*1502 haplotype, and confirmed the association of B*1502 with SJS/TEN [Pc=1.6x10, odds ratio (OR)=1357; 95% confidence interva...Continue Reading

References

Dec 14, 1995·The New England Journal of Medicine·J C RoujeauF Locati
Nov 10, 1994·The New England Journal of Medicine·J C Roujeau, R S Stern
Jun 1, 1994·The Journal of Investigative Dermatology·J C Roujeau
Jul 1, 1997·The Journal of Clinical Investigation·B SchnyderW J Pichler
Dec 11, 1999·Nucleic Acids Research·E M SmigielskiS T Sherry
Mar 29, 2002·The Journal of Investigative Dermatology·Amal NassifJean-Claude Roujeau
Sep 21, 2002·Lancet·Hugo W Tilanus
Nov 15, 2002·International Journal of Hematology·Derek Middleton
Aug 16, 2003·American Journal of Human Genetics·Emily C WalshJohn D Rioux
May 1, 1956·Annals of Human Genetics·J B HALDANE
Mar 17, 2004·Proceedings of the National Academy of Sciences of the United States of America·Annalise M MartinSimon Mallal
Apr 2, 2004·Nature·Wen-Hung ChungYuan-Tsong Chen
Nov 13, 2004·The Journal of Allergy and Clinical Immunology·Amal NassifJean-Claude Roujeau
Dec 2, 2004·Nature Reviews. Genetics·Roger HortonStephan Beck
Mar 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Shuen-Iu HungYuan-Tsong Chen
Mar 16, 2005·Toxicology·Jean-Claude Roujeau

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Citations

Jan 21, 2009·Archives of Dermatology·Rebecca J BrownEdward W Cowen
Oct 14, 2010·European Journal of Clinical Pharmacology·Sang-Heon KimYoung Koo Jee
Jun 12, 2009·Current Neurology and Neuroscience Reports·Carl W Bazil
Jun 16, 2009·Current Treatment Options in Neurology·Lynn Liu, J Craig Henry
Mar 13, 2012·Immunologic Research·Sebastien Calbo
Dec 15, 2006·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Cornelia S SeitzAxel Trautmann
May 3, 2013·Journal of Human Genetics·Nahoko Kaniwa, Yoshiro Saito
Mar 25, 2011·The New England Journal of Medicine·Pei ChenUNKNOWN Taiwan SJS Consortium
Mar 25, 2011·The New England Journal of Medicine·Mark McCormackMunir Pirmohamed
Aug 22, 2012·Human Molecular Genetics·Chun-Yu WeiYuan-Tsong Chen
Jul 14, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Satonori HiguchiTsuyoshi Yokoi
Jul 9, 2011·Pharmacogenetics and Genomics·Caroline F ThornRuss B Altman
Oct 17, 2012·Psychiatry and Clinical Neurosciences·Kuo-Chun ChaoWinston W Shen
Jul 17, 2008·Epilepsia·Wolfgang LöscherDieter Schmidt
Jun 12, 2010·Epilepsia·Chaichon LocharernkulNattiya Hirankarn
May 30, 2013·BMC Genomics·Kazuyoshi HosomichiIturo Inoue
Sep 27, 2012·Orphanet Journal of Rare Diseases·Sophie BouvresseJean-Claude Roujeau
Jun 4, 2011·Genome Medicine·Taisei Mushiroda, Yusuke Nakamura
Nov 26, 2009·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Suran L Fernando, Andrew J Broadfoot
Nov 2, 2011·Drug Metabolism and Pharmacokinetics·Chun-Yu WeiYuan-Tsong Chen
Jul 14, 2012·Drug, Healthcare and Patient Safety·Amy Z CrepeauElaine C Wirrell
Apr 21, 2009·Pharmacogenomics·Clive Bowman, Olivier Delrieu
May 20, 2009·Pharmacogenomics·Clive Bowman, Olivier Delrieu
May 20, 2009·Pharmacogenomics·Dalia Kasperaviciūte, Sanjay M Sisodiya
Mar 20, 2010·Pharmacogenomics·Laurent Becquemont
Jul 7, 2010·Pharmacogenomics·Elizabeth J Phillips, Simon A Mallal
Jul 1, 2011·Indian Journal of Dermatology·Kisalay GhoshJayoti Nandi
Jan 4, 2013·Journal of Clinical and Diagnostic Research : JCDR·Mayuresh V FegadeIan Pereira

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