Abstract
Endomyocardial fibrosis (EMF) is the most common form of restrictive cardiomyopathy worldwide. It has been linked to poverty and various environmental factors, but-for unknown reasons-only some people who live in similar conditions develop the disease. EMF cases cluster within both families and ethnic groups, suggesting a role for a genetic factor in host susceptibility. The human leukocyte antigen (HLA) system is associated with predisposition to various diseases. This two-center study was designed to investigate variation in the HLA system between EMF patients and unaffected controls. We provide the first genetic investigation of patients with EMF, as well as a comprehensive review of the literature. HLA class I (HLA-A, -B, -C) and class II (DRB1, DQB1) types were determined in 71 patients with severe EMF and 137 controls from Uganda and Mozambique. Chi Square analysis was used to identify any significant difference in frequency of class I and class II HLA types between cases and controls. Compared to ethnically matched controls, HLA-B*58 occurred more frequently in Mozambique patients with EMF and HLA-A*02:02 occurred more frequently in Ugandan patients with EMF. Ample subjective evidence in the historical literature suggest...Continue Reading
References
Sep 1, 1977·Postgraduate Medical Journal·O Hernández-Pieretti
Nov 6, 1971·British Medical Journal·A K PatelK Somers
Mar 1, 1983·Postgraduate Medical Journal·E G Olsen
Mar 1, 1983·Postgraduate Medical Journal·M S Hutt
Nov 1, 1982·British Heart Journal·J DaviesJ F Goodwin
Apr 1, 1995·Tissue Antigens·P KrausaC E Allsop
Jul 1, 1996·Tropical Doctor·J FreersM Rutakingirwa
May 1, 1999·Tropical Medicine & International Health : TM & IH·M RutakingirwaJ Freers
Sep 1, 1963·British Heart Journal·F C ADI
Jan 1, 1965·British Heart Journal·A G SHAPER, R M COLES
Jan 1, 1960·Transactions of the Royal Society of Tropical Medicine and Hygiene·A G SHAPER, A W WILLIAMS
Mar 11, 2004·Tissue Antigens·K CaoM A Fernández-Viña
Dec 14, 2004·Nature·Photini KiepielaPhilip J R Goulder
Jan 31, 2006·Tissue Antigens·Z LombardL Bornman
Feb 28, 2008·PLoS Neglected Tropical Diseases·Gene BukhmanEldryd Parry
May 21, 2008·Tissue Antigens·M Marcilla, J A López de Castro
Jul 4, 2008·The New England Journal of Medicine·Ana Olga MocumbiMagdi H Yacoub
Feb 11, 2010·Pediatric Cardiology·Nashwa El-HagrassyNabeil Joseph
Oct 29, 2010·Cardiology in the Young·Antoinette M CilliersAna O Mocumbi
Nov 27, 2010·The International Journal of Cardiovascular Imaging·A O MocumbiM Burke
Oct 18, 2011·BMC Infectious Diseases·Zilungile L Mkhize-KwitshanaGerhard Walzl
Apr 28, 2012·Tissue Antigens·R Díaz-PeñaC López-Larrea