PMID: 9185733Jun 1, 1997Paper

Genetic susceptibility to head and neck cancer: interaction between nutrition and mutagen sensitivity

The Laryngoscope
S P SchantzT C Hsu

Abstract

The development of head and neck cancer may depend not only on exposure to environmental carcinogens but also on a genetically based susceptibility to carcinogen-induced damage. This thesis presents a case-control study that demonstrates the significance of mutagen sensitivity, a measure of an individual's intrinsic DNA repair capacity against free radical damage, as a risk factor for the disease. As part of the case-control analysis, 167 previously untreated patients and 177 age- and sex-matched healthy controls were assessed for various lifestyle factors including tobacco and alcohol habits, occupational exposures, and diet. Mutagen sensitivity expressed by each individual was determined by quantifying bleomycin-induced chromosomal breaks within peripheral blood lymphocytes in vitro. Consistent with our initial observations and those of others, mutagen hypersensitivity was strongly associated with increased risk of head and neck cancer (odds ratio, 4.95; 95% confidence interval, 2.67 to 9.17) after adjusting for age, sex, and race. Low intake of vitamins C and E was also associated with an increased risk of disease and was interactive with mutagen sensitivity in risk estimates. Individuals with both a low intake of various an...Continue Reading

References

Jan 1, 1978·Mutation Research·B K Vig, R Lewis
Jan 1, 1992·Advances in Experimental Medicine and Biology·D Schottenfeld
Jun 1, 1992·Proceedings of the Society for Experimental Biology and Medicine·N I Krinsky
Mar 1, 1991·Mutation Research·L F Povirk, M J Austin
Sep 1, 1990·Mutation Research·E MullaartJ Vijg
Mar 15, 1989·International Journal of Cancer. Journal International Du Cancer·T C HsuC Furlong
Dec 15, 1989·JAMA : the Journal of the American Medical Association·S P SchantzR P Moser
Jul 1, 1989·Mutation Research·H Joenje
Nov 15, 1985·International Journal of Cancer. Journal International Du Cancer·E M de VilliersH zur Hausen
Sep 1, 1987·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·T C Hsu
Jan 1, 1985·Advances in Cancer Research·B S Strauss
Jun 1, 1974·American Journal of Epidemiology·K J Rothman
Mar 15, 1994·International Journal of Cancer. Journal International Du Cancer·J CloosG B Snow
Feb 1, 1995·The American Journal of Clinical Nutrition·D M Winn
Sep 26, 1994·The American Journal of Medicine·B Frei
Jan 1, 1993·Annual Review of Nutrition·N I Krinsky
Jan 1, 1993·Advances in Cancer Research·K C Cheng, L A Loeb
Feb 1, 1993·Clinical Genetics·A B Weitberg, D Corvese
May 28, 1993·Annals of the New York Academy of Sciences·W A Pryor, K Stone

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Citations

Jul 9, 1999·The Journal of Pathology·M G van OijenP J Slootweg
Apr 5, 2000·Head & Neck·K T PitmanE N Myers
Jul 10, 2001·Head & Neck·P L Friedlander
Apr 26, 2001·The New England Journal of Medicine·J SudbøA Reith
Nov 30, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·V EdefontiA Decarli
Jul 7, 1999·Journal of the National Cancer Institute·N Caporaso
Jun 24, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Carlotta GaleoneMia Hashibe
Jul 1, 2010·Arhiv za higijenu rada i toksikologiju·Mirta Milić
Jul 13, 2013·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Ahmad AlshadwiBrian J Daley
Aug 27, 2010·Environmental and Molecular Mutagenesis·Lynnette R Ferguson
Jul 1, 2014·International Journal of Cancer. Journal International Du Cancer·Carlotta GaleoneStefania Boccia
Mar 1, 2005·Cancer Detection and Prevention·Madeleine A Kane
Sep 1, 2004·Reproductive Toxicology·Hélder Silva LunaRodolfo Rumpf
Dec 16, 2004·Seminars in Oncology·Erich M SturgisMargaret R Spitz
Apr 14, 2000·Clinics in Chest Medicine·T M Fitzpatrick, E A Blair
Jan 30, 2015·International Journal of Cancer. Journal International Du Cancer·Valeria EdefontiAdriano Decarli
Aug 15, 2015·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Paolo BoffettaMia Hashibe
Jun 21, 2016·Regulatory Toxicology and Pharmacology : RTP·Peter N LeeJanette S Hamling
May 8, 2003·Nutrition and Cancer·Nita Chainani-Wu
Feb 22, 2000·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·T C HartJ T Wright
Aug 17, 2000·The Australian and New Zealand Journal of Surgery·B R RoseY E Cossart
Jul 16, 2017·International Journal of Cancer. Journal International Du Cancer·Daisuke KawakitaValeria Edefonti
Oct 31, 2001·Public Health Nutrition·P Vineis
Jun 29, 2012·Oncology Letters·Maximilian ReiterUlrich Harréus
Nov 30, 2019·American Journal of Epidemiology·Yuan-Chin Amy LeeMia Hashibe
Mar 8, 2018·International Journal of Molecular Medicine·Yang DingJianmin Han
Aug 25, 2020·British Journal of Cancer·Gioia Di CredicoValeria Edefonti
Jan 24, 2015·International Journal of Epidemiology·Tatiana Natasha ToporcovVictor Wünsch Filho
Mar 4, 2003·The Journal of Nutrition·Radoslav Goldman, Peter G Shields
Apr 16, 2015·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Emanuele LeonciniStefania Boccia

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