Genetic susceptibility to ozone exposure

Toxicology Letters
S R Kleeberger

Abstract

Because of the impact that oxidizing air pollutants such as ozone (O3) may have on public health, identification of factors that influence susceptibility to exposure remains a critical issue. The role of genetic background as a susceptibility factor is becoming increasingly clear. In this paper, evidence is reviewed which suggests that susceptibility to O3 is a heritable trait in humans. Experimental studies are also described that characterize the mode of inheritance of O3-induced lung injury in inbred strains of mice. It is suggested that future investigations should strive to identify phenotypic markers of susceptibility as a means to identify individuals who are genetically at risk for the development of oxidant-induced lung injury.

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Citations

Feb 7, 2002·Neurotoxicology·B Verones, M Oortgiesen
Dec 17, 1997·Nature Genetics·S R KleebergerK J Holroyd
Jan 18, 2003·Archives of Environmental Health·Alain Le TertreCorinne Le Goaster
Feb 21, 2004·American Journal of Respiratory Cell and Molecular Biology·Jordan D SavovDavid A Schwartz
Jul 27, 2007·The European Respiratory Journal·C ChenJ R Balmes
Mar 31, 2007·Seminars in Radiation Oncology·Elizabeth L Travis
Nov 15, 2000·Toxicology and Applied Pharmacology·B VeronesiS H Gavett
Aug 12, 1998·The American Journal of Physiology·G W MangoB R Stripp
Mar 11, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·Y OhtsukaS R Kleeberger

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