Genetic susceptibility to renal ischemia reperfusion injury revealed in a murine model

M J BurneH Rabb


The development of genetically engineered mice has led to increased use of mouse models to study renal ischemic reperfusion injury (IRI). We hypothesized that susceptibility to IRI could result from strain differences due to genetic factors. Our study compared recovery subsequent to renal IRI in NIH Swiss, C57BL/6, and BALB/c mice. Serum creatinine (SCr) and blood urea nitrogen (BUN) levels were evaluated postischemia. We also conducted reverse transcriptase-polymerase chain reaction (RT-PCR) analyses of renal cytokines and adhesion molecules postischemia. At 48 hr postischemia, renal dysfunction in NIH Swiss mice was significantly reduced, compared with other groups (P<0.01). BUN measurements confirmed renal protection at 48 hr in the NIH Swiss group. RT-PCR analysis of mRNA postischemia demonstrated that, between strains, there was little difference in mRNA expression for renal cytokines and adhesion molecules. NIH Swiss mice appear to be resistant in susceptibility to renal IRI. Early expression of pro-inflammatory genes was not associated with resistance to IRI, thus genetic factors could be important in outcome after renal IRI.


Feb 14, 2007·Transplantation·Maria Teresa Gandolfo, Hamid Rabb
Oct 11, 2008·Nephrology·Sean E Kennedy, Jonathan H Erlich
Sep 21, 2012·American Journal of Physiology. Renal Physiology·Qingqing Wei, Zheng Dong
Jan 13, 2011·BMC Genomics·You-Hai XuGregory A Grabowski
Jul 30, 2009·The Tohoku Journal of Experimental Medicine·Honglin HuCarole Nicco
Aug 30, 2008·Experimental Physiology·Melissa E ReicheltJohn P Headrick
Aug 31, 2013·Nucleic Acid Therapeutics·Tamás KaucsárPéter Hamar
Jan 16, 2015·The Journal of Surgical Research·Jan F GielisPaul E Y Van Schil
Jan 30, 2007·Journal of Molecular and Cellular Cardiology·Kevin J AshtonJohn P Headrick
Jun 28, 2018·American Journal of Physiology. Renal Physiology·Ying FuZheng Dong
Jun 22, 2018·Plastic and Reconstructive Surgery·Chin-Yu YangHui-Yi Hsiao
Aug 19, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Neil R Powe
Aug 15, 2019·American Journal of Physiology. Renal Physiology·Lauren ScarfeMark P de Caestecker
Feb 15, 2020·Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences·Mahsan SamadiYousof Gheisari
Apr 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chun HeStephen Tomlinson
Jun 16, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zhu-Xu ZhangAnthony M Jevnikar
Oct 22, 2002·American Journal of Physiology. Renal Physiology·H Thomas LeeCharles W Emala
Aug 17, 2006·American Journal of Physiology. Renal Physiology·Almut GrenzHolger K Eltzschig
Mar 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bart de VriesWim A Buurman
Jan 15, 2002·American Journal of Physiology. Renal Physiology·Pierce ParkRichard J Quigg
Aug 19, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Tobias EckleHolger K Eltzschig
Jan 30, 2020·Clinical Journal of the American Society of Nephrology : CJASN·Haojia Wu, Benjamin D Humphreys
Apr 24, 2003·American Journal of Physiology. Renal Physiology·Naoko YokotaHamid Rabb
Feb 18, 2021·In Vitro Cellular & Developmental Biology. Animal·Seiji KishiCraig R Brooks

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics
B A MockJ Blackwell
American Journal of Physiology. Renal Physiology
Kaoru YasudaMichael S Goligorsky
Journal of the American Society of Nephrology : JASN
Hiroyuki MatsudaJohanne Tremblay
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Zhenfeng XuRaymond C Koehler
© 2021 Meta ULC. All rights reserved