Genetic susceptibility to urinary incontinence: implication of polymorphisms of androgen and oestrogen pathways.

World Journal of Urology
J N CornuF Haab

Abstract

Although existence of genetic factors predisposing to urinary incontinence in women is widely admitted, precise molecular and genetic variations implicated are still unknown. Given the established influence of steroids metabolism in incontinence, we studied the correlation between polymorphisms of genes of oestrogen/androgen pathways and urinary incontinence in women, in order to raise evidence of genetic susceptibility. A case-control study included 121 cases and 66 controls. Age, familial history of incontinence, gynaecologic history and age of menopause were collected. Patients were classified into three groups: control, urge urinary incontinence (UUI), stress urinary incontinence (SUI). Genetic polymorphisms were determined after amplification by PCR for the following genes: CYP-19, CYP17, androgen receptor (AR) and oestrogen receptor (ESR-1). Statistical analysis was performed to study correlation between genotype and presence of a subtype of incontinence. A total of 187 patients were analysed: 66 were controls, 30 presented UUI and 107 presented SUI. Patients presenting incontinence had significantly more often familial history of incontinence than controls. AR polymorphism (combination of 2 alleles containing more than 2...Continue Reading

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Citations

Sep 1, 2012·Women's Health·Rosamund GrimshawPallavi Latthe
Aug 12, 2014·American Journal of Obstetrics and Gynecology·Rufus CartwrightVik Khullar
Sep 21, 2016·Menopause : the Journal of the North American Menopause Society·Angelo CagnacciAnjeza Xholli
Jan 24, 2018·Electrophoresis·Marianne KochGoran Mitulović
Feb 5, 2019·International Urogynecology Journal·Theresa ReischerMarianne Koch
Mar 13, 2019·Climacteric : the Journal of the International Menopause Society·S L Johnston
Sep 20, 2020·Neurourology and Urodynamics·Wilke M PostKirsten B Kluivers
Mar 21, 2021·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Jinyi ZhangYue Hu

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