Genetic testing of newborns for type 1 diabetes susceptibility: a prospective cohort study on effects on maternal mental health.

BMC Medical Genetics
Kaja K AasKjersti S Rønningen

Abstract

Concerns about the general psychological impact of genetic testing have been raised. In the Environmental Triggers of Type 1 Diabetes (MIDIA) study, genetic testing was performed for HLA-conferred type 1 diabetes susceptibility among Norwegian newborns. The present study assessed whether mothers of children who test positively suffer from poorer mental health and well-being after receiving genetic risk information about their children. The study was based on questionnaire data from the Norwegian Mother and Child Cohort (MoBa) study conducted by the Norwegian Institute of Public Health. Many of the mothers in the MoBa study also took part in the MIDIA study, in which their newborn children were tested for HLA-conferred genetic susceptibility for type 1 diabetes. We used MoBa questionnaire data from the 30th week of pregnancy (baseline) and 6 months post-partum (3-3.5 months after disclosure of test results). We measured maternal symptoms of anxiety and depression (SCL-8), maternal self-esteem (RSES), and satisfaction with life (SWLS). The mothers also reported whether they were seriously worried about their child 6 months post-partum. We compared questionnaire data from mothers who had received information about having a newborn...Continue Reading

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Citations

Aug 21, 2013·Archivum Immunologiae Et Therapiae Experimentalis·Kjersti S Rønningen
Jun 29, 2011·Current Diabetes Reports·Suzanne Bennett Johnson
Nov 19, 2013·Genome Génome / Conseil National De Recherches Canada·S G NichollsJ Little
Apr 18, 2015·BioMed Research International·Kjersti S Rønningen

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Methods Mentioned

BETA
genotyping

Software Mentioned

MIDIA
SPSS
MoBa

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