Genetic testing on products of conception and its relationship with body mass index.

Journal of Assisted Reproduction and Genetics
Linlin WangYingpu Sun

Abstract

The study aimed to investigate the relationship between elevated maternal body mass index (BMI) and foetal chromosomal aberrations by performing single-nucleotide polymorphism (SNP) array-based genetic testing on products of conception (POC). We retrospectively reviewed the data for 1068 assisted reproductive technology (ART)-conceived POC originated from 1068 patients with early spontaneous miscarriage. First, all types of chromosomal abnormalities were defined. Then, the baseline characteristics, including maternal age, BMI, thyroid-stimulating hormone (TSH), gestational age, fertilization method, reasons for fertility treatment, embryo transfer (ET) cycle, stage of embryo development and the embryo morphology grade, were compared between chromosomally normal and abnormal POC groups. Finally, a multivariate logistic regression model was used to analyse various factors affecting the foetal chromosomal abnormality rate. The SNP array results showed that 45.3% (484/1068) of POC were chromosomally normal and that 54.7% (584/1068) of POC presented chromosomal abnormalities. Of these 584 chromosomally abnormal POC, 388 (66.4%) were trisomy, 42 (7.2%) had a monosomy, 68 (11.6%) were found with segmental aneuploidy, 46 (7.9%) were mo...Continue Reading

References

Dec 18, 2002·Journal of Assisted Reproduction and Genetics·Ruth B Lathi, Amin A Milki
May 3, 2003·American Journal of Epidemiology·Rémy SlamaWolfgang Härdle
Dec 23, 2003·Human Reproduction·UNKNOWN Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group
May 14, 2004·Human Reproduction Update·Robert J NormanJim X Wang
Apr 20, 2005·Nature Genetics·Kevin L GundersonMark S Chee
Nov 25, 2006·Fertility and Sterility·M Cristina MagliValeria Farfalli
Apr 25, 2007·Fertility and Sterility·Sharon E MoayeriLawrence B Werlin
May 15, 2007·Current Opinion in Obstetrics & Gynecology·Elizabeth E Puscheck, Rajasingam S Jeyendran
Sep 5, 2007·Nature Genetics·Charles LeeArthur R Brothman
Mar 2, 2010·Human Reproduction·Inna V LandresRuth B Lathi
May 25, 2010·Obstetrics and Gynecology Clinics of North America·Gary Fruhman, Ignatia B Van den Veyver
Mar 15, 2012·Molecular Cytogenetics·Malgorzata I SrebniakRobert-Jan H Galjaard
Oct 16, 2012·Fertility and Sterility·Bruce S ShapiroCynthia Hudson
Nov 5, 2013·Molecular Human Reproduction·E FragouliD Wells
Jun 9, 2014·Fertility and Sterility·Christina E BootsMary D Stephenson
Jan 16, 2015·Best Practice & Research. Clinical Obstetrics & Gynaecology·Mayumi Sugiura-Ogasawara
Jan 27, 2015·Best Practice & Research. Clinical Obstetrics & Gynaecology·Alon Talmor, Bruce Dunphy
Feb 13, 2015·Molecular Cytogenetics·Jiadi WenEvica Rajcan-Separovic
Jun 14, 2015·Molecular Human Reproduction·Hani BagheriEvica Rajcan-Separovic
Jul 19, 2016·American Journal of Obstetrics and Gynecology·UNKNOWN Society for Maternal-Fetal Medicine (SMFM). Electronic address: pubs@smfm.orgJeffrey A Kuller
Dec 30, 2016·Future Science OA·Hind N MoussaBaha M Sibai
Jan 7, 2017·Thyroid : Official Journal of the American Thyroid Association·Erik K AlexanderScott Sullivan

❮ Previous
Next ❯

Citations

Oct 4, 2021·Human Reproduction·José BellverMarcos Meseguer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

CAP Today
D M VeillonJ D Cotelingam
American Journal of Perinatology
Dalibor KurepaJohn Amodio
Open Access Emergency Medicine : OAEM
Karalee QuigMatthew O'Hara
© 2022 Meta ULC. All rights reserved