PMID: 9434858Jan 22, 1998Paper

Genetic toxicities of human teratogens

Mutation Research
J B BishopR A Sloane

Abstract

Birth defects cause a myriad of societal problems and place tremendous anguish on the affected individual and his or her family. Current estimates categorize about 3% of all newborn infants as having some form of birth defect or congenital anomaly. As more precise means of detecting subtle anomalies become available this estimate, no doubt, will increase. Even though birth defects have been observed in newborns throughout history, our knowledge about the causes and mechanisms through which these defects are manifested is limited. For example, it has been estimated that around 20% of all birth defects are due to gene mutations, 5-10% to chromosomal abnormalities, and another 5-10% to exposure to a known teratogenic agent or maternal factor [D.A. Beckman, R.L. Brent, Mechanisms of teratogenesis. Ann. Rev. Pharmacol. Toxicol. 24 (1984) 483-500; K. Nelson, L.B. Holmes Malformations due to presumed spontaneous mutations in newborn infants, N. Engl. J. Med. 320 (1989) 19-23.]. Together, these percentages account for only 30-40%, leaving the etiology of more than half of all human birth defects unexplained. It has been speculated that environmental factors account for no more than one-tenth of all congenital anomalies [D.A. Beckman, R...Continue Reading

References

Nov 1, 1976·Mutation Research·P Maier, W Schmid
Jan 1, 1977·Mutation Research·G W Grigg
Aug 1, 1977·Mutation Research·B GutterH S Rosenkranz
Dec 1, 1977·American Journal of Diseases of Children·G L FeldmanE W Lovrien
Apr 1, 1978·Teratology·R L Brent
Jan 1, 1977·Advances in Experimental Medicine and Biology·F M BadrF H Hussain
Dec 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J McCannB N Ames
Nov 15, 1975·International Journal of Cancer. Journal International Du Cancer·H R GlattS Garattini
Apr 1, 1975·Mutation Research·N P BishunD C Williams
Jan 1, 1992·Teratogenesis, Carcinogenesis, and Mutagenesis·D KindigJ E Beyers
Jan 1, 1992·Mutation Research·A F McFeeM D Shelby
Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·L R FergusonP Morecombe
Aug 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·T J McBrideL A Loeb
Jan 1, 1992·Environmental and Molecular Mutagenesis·E ZeigerK Mortelmans
Jan 1, 1990·Developmental Biology·S M Sato, T D Sargent
Mar 1, 1990·Journal of Leukocyte Biology·M T LeeM B Ladner
Jan 1, 1991·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·G Lunn, E B Sansone
Jan 1, 1991·Environmental and Molecular Mutagenesis·D B McGregorW J Caspary
May 1, 1991·Carcinogenesis·A Gladek, J G Liehr
Jul 1, 1991·Mutation Research·K D Beaula Helen, S Subramanyam
Aug 1, 1991·Mutation Research·U H Ehling, A Neuhäuser-Klaus
Jan 1, 1990·Environmental and Molecular Mutagenesis·B E AndersonK S Loveday
Jan 1, 1990·Environmental and Molecular Mutagenesis·B MyhrW J Caspary
Jan 1, 1990·Environmental and Molecular Mutagenesis·E D WagnerM J Plewa
Aug 1, 1990·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·J R BucherH A Ragan
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J T MacGregorB N Ames
Dec 17, 1990·Toxicology·M L WeinerL L Yang

❮ Previous
Next ❯

Citations

Sep 3, 1999·Teratology·J M Trasler, T Doerksen
Oct 6, 1999·Teratology·J GómezH S Rosenkranz
Sep 19, 2000·Teratogenesis, Carcinogenesis, and Mutagenesis·S TeoS Thomas
Apr 23, 2002·Teratology·Janine E Polifka, J M Friedman
Nov 13, 2002·Mutation Research·Robert K Vinson, Barbara F Hales
Jan 22, 1998·Mutation Research·L R Ferguson, J H Ford
Dec 5, 1998·Mutation Research·H S RosenkranzG Klopman
Dec 17, 2009·Evidence-based Complementary and Alternative Medicine : ECAM·Gunjan GuhaLazar Mathew
Jan 25, 2002·Annual Review of Pharmacology and Toxicology·Richard H FinnellThomas H Rosenquist
Aug 22, 2002·Psychosomatics·Päivi A PynnönenVeikko A Aalberg
Oct 25, 2011·Journal of the American Academy of Dermatology·Yoon-Soo Cindy BaeUNKNOWN National Psoriasis Foundation
May 21, 2013·American Journal of Medical Genetics. Part a·Antonio Morales-PigaGonzalo López-Abente
May 11, 2007·Clinical Genetics·D GenevièveS Lyonnet
Jun 15, 2000·Regulatory Toxicology and Pharmacology : RTP·H S Rosenkranz, A R Cunningham
May 27, 2005·Current Opinion in Genetics & Development·Barbara F Hales
May 29, 2003·Birth Defects Research. Part A, Clinical and Molecular Teratology·Lihadh I Al-GazaliAden Kula Dawodu
Apr 19, 2005·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Barbara GrajewskiMelissa A McDiarmid
Mar 29, 2003·The Journal of Perinatal & Neonatal Nursing·Jackie TillettLeona VandeVusse
Mar 8, 2018·Current Protocols in Toxicology·Anthony FlamierTheodore P Rasmussen
Jul 25, 2019·International Journal of Environmental Research and Public Health·Yufeng MaMei Qiang
Apr 6, 2004·Journal of Andrology·Alexis M CodringtonBernard Robaire
Aug 18, 2018·Archives of Toxicology·Nuno Guerreiro Oliveira, Ricardo Jorge Dinis-Oliveira
Dec 23, 2020·Environmental Toxicology·Suyane da Silva MoreiraArielle Cristina Arena

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.