PMID: 8980694Dec 12, 1996Paper

Genetic toxicity of cytokines

Mutation Research
J R Lazutka

Abstract

Review of the literature shows that such cytokines as human interferons alpha and gamma, tumor necrosis factor alpha, epidermal growth factor and interleukin-2 may exhibit genotoxic properties in human peripheral blood lymphocyte cultures. For all above cytokines, except interleukin-2, parabolic-like relationship between the dose and the frequency of sister chromatid exchanges was found. Although the mechanisms of these genotoxic actions remain largely unknown, generation of free radicals or interaction with enzymes such as DNA topoisomerase II may be suspected. Human interferon alpha also may be considered as an antimutagenic compound in human cells. Human tumor necrosis factor alpha has been reported to enhance cytotoxicity and DNA fragmentation produced by DNA topoisomerase II-targeted anticancer drugs. At the same time, it has some radio- and chemoprotective properties in vitro and in vivo. Despite these facts, the question about genotoxicity of cytokines is not answered. Some problems must be resolved before receiving the final answer. First, much more cytokines must be tested for their genotoxic activity. Second, appropriate test-systems must be designed. Third, genotoxicity studies of cytokines must account for cytokine ...Continue Reading

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Citations

May 17, 2003·Birth Defects Research. Part A, Clinical and Molecular Teratology·Janine E Polifka, J M Friedman
Oct 7, 2004·Toxicology in Vitro : an International Journal Published in Association with BIBRA·A D BolzánM S Bianchi
Apr 17, 2001·Gut·R J Playford
Apr 29, 2009·International Journal of Molecular Sciences·Lim Chin Keong, Ahmad Sukari Halim
Jun 15, 2016·Journal of Immunotoxicology·Alfredo SantovitoMassimiliano Delpero
Jul 16, 2009·Cancer Genetics and Cytogenetics·Sofia BakaZafiroula Iakovidou-Kritsi
Apr 27, 2011·International Journal of Cancer. Journal International Du Cancer·Aya M WestbrookRobert H Schiestl
Nov 29, 2014·Pharmaceutical Biology·Nathalia Novak ZobioleFrancielle Tramontini Gomes de Sousa Cardozo

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