PMID: 2125330Nov 1, 1990Paper

Genetic toxicity of six carcinogens and six non-carcinogens in the Drosophila wing spot test

Mutation Research
N K TripathyH Frei

Abstract

Six rodent carcinogens, 5 of which are also human carcinogens, and 6 compounds recognized as non-carcinogens were tested for their genotoxic activity in the Drosophila melanogaster wing spot test. 72-h-old larvae trans-heterozygous for the recessive wing cell markers 'multiple wing hairs' (mwh) and 'flare' (flr3) were fed various concentrations of the test compounds for a period of 48 h. With amitrole and 4-aminobiphenyl, larvae of the same age were also given an acute treatment of 6 h with higher concentrations, and, in addition, 48-h-old larvae were fed for a longer period of 72 h. Repeats of all experiments document the good reproducibility of the results in the wing spot test. Amitrole and 4-aminobiphenyl were genotoxic after both 48-h and 72-h treatments, but their activity could not be detected following acute exposure of only 6 h. Chlorambucil and melphalan were clearly genotoxic. The carcinogens sodium arsenite and sodium arsenate, however, which are highly toxic to Drosophila, could only be tested at low exposure levels and were negative under these treatment conditions. The 6 non-carcinogens (ascorbic acid, 2-aminobiphenyl, mannitol, piperonyl butoxide, stannous chloride and titanium dioxide) were all definitely non-g...Continue Reading

References

Jun 1, 1975·Mutation Research·H Nishioka
Sep 1, 1976·Mutation Research·D V Martensen, M M Green
Dec 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J McCannB N Ames
Apr 1, 1989·Mutation Research·U GrafF E Würgler
Jul 1, 1989·Mutation Research·I D AdlerF E Würgler
Mar 1, 1984·Mutation Research·R J Shamberger
Apr 1, 1983·Mutation Research·E P NorkusA H Conney
Jan 1, 1984·Environmental Mutagenesis·U GrafP G Kale
Sep 1, 1983·Chemico-biological Interactions·J R McLeanJ G Kaplan
Feb 1, 1980·Mutation Research·N KanematsuT Kada
Jan 1, 1980·Mutation Research·A Léonard, R R Lauwerys
Apr 1, 1982·Mutation Research·H OhnoM Yamada
Feb 1, 1980·Cancer Letters·M P RosinH F Stich

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Citations

Feb 13, 2002·Electrophoresis·Michaela Kohlícková-KoudelkováZdenek Deyl
Oct 22, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·F J S DantasA Caldeira-de-Araújo
Oct 1, 1996·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·F J DantasA Caldeira-de-Araújo
Dec 23, 1998·Toxicology Letters·M L AssisM Bernardo-Filho
May 26, 1998·Environmental Health Perspectives·L Lagadic, T Caquet
Oct 19, 2006·Nuclear Medicine and Biology·Anderson P GuedesAdriano Caldeira-de-Araujo
Jul 27, 2005·Ecotoxicology and Environmental Safety·Giovanni Pontecorvo, Stefania Fantaccione
Jun 2, 2005·Mutation Research·C PungartnikM Brendel
Sep 16, 2008·Mutation Research·Aida I El-MakawyWagdy K B Khalil
Jan 1, 1995·Environmental and Molecular Mutagenesis·P Ramos-Morales, R Rodríguez-Arnaiz

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