PMID: 6406880Jun 1, 1983Paper

Genetic toxicology of ethylenediaminetetraacetic acid (EDTA)

Mutation Research
K HeindorffR Rieger

Abstract

EDTA and its salts have a number of applications in medicine and pharmacy. EDTA is used to remove calcium from the human body, and serves as an anticoagulant and as a detoxicant after poisoning by heavy metals. It is often used in analytical chemistry for complexometric titrations and many other purposes. Because the compound is of rather low toxicity, it is used as a food additive to bind metal ions. EDTA affects the inhibition of DNA synthesis in primary cultures of mammalian cells. This may be due to impairment of enzymes involved in DNA replication. Some early studies have shown that EDTA leads to morphological changes of chromatin and chromosome structure in plant and animal cells. These alterations consist of dispersion or swelling of chromosomes or a loss of interphase chromatin structure. For several test systems, a low chromosome-breaking activity of EDTA has been reported. A weak activity in the induction of gene mutations has also been observed. It is well established that EDTA influences chromosome breakage by mutagenic agents. In particular, when applied in combination with chemical mutagens, EDTA enhances mutagen-induced aberration frequencies. Furthermore, the chelating agent is able to increase the incidence of ...Continue Reading

References

Dec 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J McCannB N Ames
Dec 1, 1976·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·G A LeontjevaA I Gaziev
Nov 1, 1966·Experimental Cell Research·Y Okada, F Murayama
Jun 14, 1969·Nature·C J DeanP Alexander
Aug 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·E Robbins, T Pederson
Jan 1, 1967·Molecular & General Genetics : MGG·Z SwietlińskaJ Zbrzeska
Apr 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·L M Chang, F J Bollum
Jan 1, 1971·Toxicology and Applied Pharmacology·A L Aronson, F A Ahrens
Aug 14, 1980·Biochemical and Biophysical Research Communications·Y HiraokaN Murai
Apr 1, 1957·Experimental Cell Research·M R MCDONALD, B P KAUFMANN
Jan 1, 1956·Cold Spring Harbor Symposia on Quantitative Biology·B P KAUFMANN, M R MCDONALD
Apr 1, 1958·Experimental Cell Research·D DAVIDSON
Jan 1, 1958·Zeitschrift für Vererbungslehre·R P LEVINE, W T EBERSOLD
Jan 1, 1961·International Review of Cytology·D M STEFFENSEN
Oct 17, 1962·Biochemical and Biophysical Research Communications·A MICHAELISR RIEGER
May 18, 1963·Lancet·V R BASRUR, D G BAKER
Apr 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·L LEIVE
Jun 1, 1954·Proceedings of the National Academy of Sciences of the United States of America·D Mazia
Oct 15, 1955·Proceedings of the National Academy of Sciences of the United States of America·R P Levine
Feb 1, 1956·Proceedings of the National Academy of Sciences of the United States of America·R A Eversole, E L Tatum
Aug 1, 1956·Proceedings of the National Academy of Sciences of the United States of America·S Wolff, H E Luippold
Mar 15, 1957·Proceedings of the National Academy of Sciences of the United States of America·B P KaufmannM J McElderry
Mar 15, 1957·Proceedings of the National Academy of Sciences of the United States of America·B P Kaufmann, M R McDonald

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Citations

Nov 5, 1999·Journal of Applied Toxicology : JAT·M O Ogundele
Apr 1, 1985·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J Ashby
Dec 1, 1991·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association· Muralidhara, K Narasimhamurthy
Feb 24, 2000·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J HeimbachJ Borzelleca
Aug 1, 1997·Mutation Research·M Paolini, G Cantelli-Forti
Jun 28, 2005·Toxicology Letters·Daniela L Oberreuther-MoschnerBeatrice L Pool-Zobel
Jan 1, 1985·Environmental Mutagenesis·J Ashby, I F Purchase
May 19, 2019·Environmental Science and Pollution Research International·Celeste Es Ruiz de ArcauteMarcelo L Larramendy

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