Genetic transformation of mosquitoes: a quest for malaria control

International Journal for Parasitology
Luciano A MoreiraMarcelo Jacobs-Lorena

Abstract

Malaria inflicts an enormous toll in human lives and this burden is increasing. Present means to fight the disease, such as drugs and insecticides, are insufficient. Moreover, an effective vaccine has not yet been developed. This review examines an alternative strategy for malaria control, namely the genetic modification of mosquitoes to make them inefficient vectors for the parasite. The article summarises progress made toward the development of transposable element vectors for germ line transformation and the search for mosquito markers of transformation. Also reviewed is the search for anti-malarial effector genes whose products can inhibit development of the parasite in the mosquito with minimal fitness burden. While much progress has been made, much work remains to be done. Future research directions are discussed.

References

Aug 7, 2003·Trends in Parasitology·Mark Q Benedict, Alan S Robinson
Oct 5, 2010·Cold Spring Harbor Protocols·Anthony ClemonsMolly Duman-Scheel
Jan 31, 2007·BMC Genomics·Emma WarrGeorge Dimopoulos
Nov 19, 2003·PLoS Biology·Vincent P Alibu, Thomas G Egwang
Dec 21, 2004·Journal of Medical Entomology·Akio MoriDavid W Severson
Sep 2, 2008·Journal of Theoretical Biology·M RafikovA P P Wyse
Jan 30, 2007·Insect Molecular Biology·J IsoeR L Miesfeld
Jul 31, 2013·Journal of Peptide Science : an Official Publication of the European Peptide Society·Mayra ChamlianVani Xavier Oliveira
May 13, 2014·Journal of Peptide Science : an Official Publication of the European Peptide Society·Adriana Farias SilvaVani Xavier Oliveira
Sep 18, 2012·Revista Do Instituto De Medicina Tropical De São Paulo·André Barretto Bruno Wilke, Mauro Toledo Marrelli
Feb 9, 2007·DNA Sequence : the Journal of DNA Sequencing and Mapping·Sung-Jae ChaDavid W Severson

Citations

Jan 1, 1989·Medical and Veterinary Entomology·A C MorrisJ M Crampton
Oct 22, 1982·Science·G M Rubin, A C Spradling
Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·B Xiong, Marcelo Jacobs-Lorena
Jul 8, 1994·Molecular & General Genetics : MGG·D A O'BrochtaP W Atkinson
Feb 27, 1997·Molecular & General Genetics : MGG·C J CoatesP W Atkinson
Aug 1, 1997·Insect Molecular Biology·C J CoatesA A James
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·N JasinskieneF H Collins
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·C J CoatesA A James
May 7, 1998·Insect Biochemistry and Molecular Biology·M J EdwardsMarcelo Jacobs-Lorena
Dec 10, 1999·Nature·A J BerghammerErnst A Wimmer
Jan 15, 2000·Insect Molecular Biology·A M Handler, R A Harrell
Feb 15, 2000·Insect Molecular Biology·A C PinkertonP W Atkinson
Feb 15, 2000·Insect Molecular Biology·N JasinskieneA A James
Feb 15, 2000·Insect Molecular Biology·M J EdwardsMarcelo Jacobs-Lorena
Feb 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·Flaminia CatterucciaT G Loukeris
Apr 1, 2000·Science·M Enserink
Apr 27, 2000·Parasitology Today·A K GhoshMarcelo Jacobs-Lorena
May 29, 2000·Parasitology Today·K D RamaiahH Guyatt
Jul 19, 2000·Insect Biochemistry and Molecular Biology·G L GrossmanMark Q Benedict
Jul 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·V A KokozaA S Raikhel
Sep 27, 2000·Proceedings of the National Academy of Sciences of the United States of America·Luciano A MoreiraMarcelo Jacobs-Lorena
Jan 11, 2001·Development Genes and Evolution·C HornErnst A Wimmer
May 29, 2001·Archives of Insect Biochemistry and Physiology·L ShaoMarcelo Jacobs-Lorena
Oct 3, 2001·Journal of Medical Entomology·M L AllenC S Levesque
Nov 1, 2001·Proceedings of the National Academy of Sciences of the United States of America·A K GhoshMarcelo Jacobs-Lorena
Dec 19, 2001·Emerging Infectious Diseases·M R SardelisM L O'Guinn
May 25, 2002·Nature·Junitsu ItoMarcelo Jacobs-Lorena
Aug 9, 2002·The Journal of Biological Chemistry·Luciano A MoreiraMarcelo Jacobs-Lorena

Related Concepts

Transformation, Genetic
Germ-Line Mutation
Insect Vectors
Genetic Markers
Malaria
Malaria Vaccines
Cloning Vectors
Germ Line
Parasites
Culicidae

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