Genetic transmission of retroviral genes and cellular oncogenes

Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character
G J TodaroJ E De Larco

Abstract

Several different families of retrovirus genome have been found to exist, each in multiple copies, in the cellular DNA of rodents and primates. There are at least four distinct families of genome in rodents: two type C families, the MTV family and another related to mouse type A particles. In primates there are also at least two families of endogenous type C virogenes and a third type D virogene family. Both in rodents and in primates, the virus-related sequences constitute almost 0.1% of the cellular genome. We have been able to generate transforming viruses, starting with endogenous mouse 'helper' type C viruses by passing them through chemically transformed mouse cells and selecting for variant viruses that have acquired the ability to induce normal cells to display anchorage-independent growth. These viruses produce both sarcomas and carcinomas in the animal; clones that produce only pulmonary carcinomas have also been selected. These presumably have arisen by recombination between the helper and 'transforming' sequences derived from the cells. Moloney sarcoma virus-transformed cells produce a new peptide, called sarcoma growth factor (SGF), that makes normal cells take on some of the properties of transformed cells. Studie...Continue Reading

Citations

Sep 1, 1983·Die Naturwissenschaften·R Kurth
Mar 14, 2000·Oncogene·R C Humphreys, L Hennighausen
Aug 1, 1982·Parasitology·A A Newton

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