Genetic variability in susceptibility and response to toxicants

Toxicology Letters
M C MillerD A Bell

Abstract

Everyone has a unique combination of polymorphic traits that modify susceptibility and response to drugs, chemicals and carcinogenic exposures. The metabolism of exogenous and endogenous chemical toxins may be modified by inherited and induced variation in CYP (P450), acetyltransferase (NAT) and glutathione S-transferase (GST) genes. We observe that specific 'at risk' genotypes for GSTM1 and NAT1/2 increase risk for bladder cancer among smokers. Genotypic and phenotypic variation in DNA repair may affect risk of somatic mutation and cancer. Variants of base excision and nucleotide excision repair genes (XRCC1 and XPD) appear to modify exposure-induced damage from cigarette smoke and radiation. We are currently engaged in discovering genetic variation in environmental response genes and determining if this variation has any effect on gene function or if it is associated with disease risk. These and other results are discussed in the context of evaluating inherited or acquired susceptibility risk factors for environmentally caused disease.

References

Nov 11, 1975·Journal of the National Cancer Institute·J F Fraumeni
Apr 1, 1975·Acta Medica Scandinavica·A J JounelaM J Mattila
Feb 15, 1992·The Biochemical Journal·B MannervikW R Pearson
Jun 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M BlumU A Meyer
Dec 1, 1991·Japanese Journal of Cancer Research : Gann·K Kawajiri, Y Fujii-Kuriyama
Jul 1, 1991·Chemical Research in Toxicology·F P Guengerich, T Shimada
Nov 1, 1991·Clinical Pharmacology and Therapeutics·M J RatainJ Smiddy
Apr 1, 1991·Mutation Research·D W Nebert
Apr 1, 1991·Mutation Research·G S Omenn
Jul 15, 1990·International Journal of Cancer. Journal International Du Cancer·J C WohllebN P Lang
Jan 1, 1989·Journal of Inherited Metabolic Disease·C R Scriver
Jan 1, 1989·Journal of Inherited Metabolic Disease·D A Gibbs
Jan 1, 1988·CRC Critical Reviews in Biochemistry·B Mannervik, U H Danielson
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J SeidegårdW R Pearson
May 1, 1972·Clinical Pharmacology and Therapeutics·R Zacest, J Koch-Weser
Jan 1, 1984·European Journal of Clinical Pharmacology·L E RamsayS Freestone
Nov 1, 1995·American Journal of Surgery·Z TriznaH Goepfert
Dec 18, 1995·Biochimica Et Biophysica Acta·L MaA J van der Eb
Jul 1, 1995·Mutation Research·T D TlstyA White
Oct 1, 1994·Environmental Health Perspectives·J S FeltonR Wu
Oct 1, 1994·Environmental Health Perspectives·P Vineis
Jan 1, 1993·Advances in Clinical Chemistry·G J Beckett, J D Hayes
Jan 1, 1993·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·D Sheehan, J P Casey
Oct 1, 1995·Trends in Biochemical Sciences·A R Lehmann
Oct 1, 1995·Trends in Biochemical Sciences·D B Zamble, S J Lippard
Feb 15, 1996·Mutation Research·B C BroughtonA R Lehmann
Jan 1, 1996·Annual Review of Biochemistry·A Sancar
Oct 2, 1996·Journal of the National Cancer Institute·S G Chaney, A Sancar
Nov 13, 1996·JAMA : the Journal of the American Medical Association·H J Lin

❮ Previous
Next ❯

Citations

Apr 1, 2005·Pathology Oncology Research : POR·Semra DemokanNejat Dalay
Mar 17, 2005·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Maria Grazia AndreassiEugenio Picano
Dec 11, 2008·Biochemical Genetics·Chao WangSongbin Fu
Apr 6, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Chibo Liu, Haibao Wang
Feb 26, 2010·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Gary GinsbergBabasaheb Sonawane
Nov 17, 2005·Carcinogenesis·R A CrallanJ Southgate
Jan 15, 2011·Journal of Nucleic Acids·Bo Hang
Aug 28, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Qing WangHengguan Cui
Dec 10, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jianchun GuLi Zhang
Nov 4, 2008·Clinical and Experimental Medicine·João Paulo Souto GrandoIlce Mara de Syllos Cólus
Sep 21, 2010·Biochemical and Biophysical Research Communications·Shruta S DadarkarMuralidhara Padigaru
Jul 26, 2011·Current Rheumatology Reports·Ryan A Hoovestol, Ted R Mikuls
Mar 19, 2013·World Journal of Surgical Oncology·Yeqing MaoLiping Xie
Nov 7, 2003·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Yongliang LiPaul W Brandt-Rauf
Apr 22, 2004·Genes, Chromosomes & Cancer·Sara Gutiérrez-EnríquezJanet Hall
Nov 20, 2004·International Journal of Cancer. Journal International Du Cancer·Ying Chuan Hu, Steven A Ahrendt
Sep 14, 2007·The Journal of Dermatological Treatment·Judith H J RoelofzenLambertus A L M Kiemeney
Dec 11, 2007·Anais Da Academia Brasileira De Ciências·Paula A OliveiraCarlos Lopes
Jul 31, 2010·Human & Experimental Toxicology·Ted Simon
Oct 13, 2011·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Kumar Saurabh, Devendra Parmar
Feb 11, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Sarah HasanAbid Azhar
Jan 20, 2018·Experimental Biology and Medicine·Yun-Peng LiYue-Xian Guo
Jan 14, 2020·The Journal of Clinical Investigation·Eugene MelamudGarret A FitzGerald
Oct 21, 2004·Cancer Investigation·Steven M Townson
Nov 1, 2007·Proteomics. Clinical Applications·Ming D Li, Ju Wang
Aug 23, 2018·Revista da Associação Médica Brasileira·Marcelo Silva, Maria da Gloria Carvalho
Oct 9, 2004·Cell Biochemistry and Function·Lülüfer TamerSüha Aydin
Dec 13, 2005·Nature Clinical Practice. Oncology·John D Potter
Aug 16, 2005·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Y LiP W Brandt-Rauf

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.