PMID: 11324755Apr 28, 2001Paper

Genetic variability of HIV-1 protease from Nigeria and correlation with protease inhibitors drug resistance

Virus Genes
A C VicenteAmilcar Tanuri

Abstract

In Nigeria, the most populous country in Africa, the characterization of HIV-1 strains has been limited. In this study we evaluated the genetic diversity of the protease coding region, one of the anti-retroviral therapy target, and investigated the presence of mutations related to resistance to HIV protease inhibitors. We analyzed samples collected during 1996 and all patients were anti-retroviral drug naïves. Ten samples were evaluated by sequencing of the protease gene. The majority, 80%, were classified as subtype A and the two others were unclassified-divergent strains, something in between A and G subtypes. The gag region from these outliners were sequenced and the phylogenetic analysis classified them as subtype G. The protease amino acid consensus sequence of the Nigerian subtype A are in complete agreement with the consensus A differing from the USA subtype B consensus in 10 positions (L10V, I13V, K14R, I15V, K20I, M36I, R41K, P63L, H69K and L89M). The secondary substitutions associated with protease inhibitor resistance were observed in all Nigerian sequences at the positions L10V, M36I and L89M. The majority of sequence variation was concentrated in the interval between aminoacids 70-90 where the protease substrate bi...Continue Reading

Citations

Jan 28, 2006·AIDS Research and Human Retroviruses·Simon M AgwaleRainer Ziermann
Jul 23, 2009·Expert Review of Anti-infective Therapy·Giordano MadedduMaria Stella Mura
Aug 28, 2009·The Journal of Antimicrobial Chemotherapy·Esmeralda A SoaresMarcelo A Soares

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