Genetic variability of inflammation and oxidative stress genes does not play a major role in the occurrence of adverse events of dopaminergic treatment in Parkinson's disease

Journal of Neuroinflammation
Sara RedenšekVita Dolzan

Abstract

Inflammation and oxidative stress are recognized as important contributors to Parkinson's disease pathogenesis. As such, genetic variability in these pathways could have a role in susceptibility for the disease as well as in the treatment outcome. Dopaminergic treatment is effective in management of motor symptoms, but poses a risk for motor and non-motor adverse events. Our aim was to evaluate the impact of selected single-nucleotide polymorphisms in genes involved in inflammation and oxidative stress on Parkinson's disease susceptibility and the occurrence of adverse events of dopaminergic treatment. In total, 224 patients were enrolled, and their demographic and clinical data on the disease course were collected. Furthermore, a control group of 146 healthy Slovenian blood donors were included for Parkinson's disease' risk evaluation. Peripheral blood was obtained for DNA isolation. Genotyping was performed for NLRP3 rs35829419, CARD8 rs2043211, IL1β rs16944, IL1β rs1143623, IL6 rs1800795, CAT rs1001179, CAT rs10836235, SOD2 rs4880, NOS1 rs2293054, NOS1 rs2682826, TNF-α rs1800629, and GPX1 rs1050450. Logistic regression was used for analysis of possible associations. We observed a nominally significant association of the IL1β...Continue Reading

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Citations

Sep 8, 2020·Pharmacogenomics·Sara Redenšek, Vita Dolžan
Oct 15, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S JesúsP Mir
Jan 23, 2021·Antioxidants·Tina LevstekKatarina Trebušak Podkrajšek
Apr 4, 2021·Journal of Clinical Medicine·Makedonka Atanasovska VelkovskaBarbara Cvenkel
Apr 20, 2021·Parkinsonism & Related Disorders·Johann FaouziJean-Christophe Corvol
Jun 10, 2021·Medicinal Research Reviews·Ramón CacabelosJuan C Carril

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Methods Mentioned

BETA
genotyping

Software Mentioned

SPSS Statistics
PS Power

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