Abstract
Platelet membrane glycoprotein (GP) Ibalpha is a critical component of platelet adhesion complex to subendothelium structures following tissue injury or pathological surfaces, such as atherosclerotic plaques. Polymorphisms of the GPIbalpha gene have been associated with a high risk for occlusive vascular disease, and its distribution varies considerably among distinct populations. These polymorphisms comprise the human platelet antigen (HPA)-2 system, the -5C/T dimorphism of the Kozak sequence, and the variable number of tandem 39-bp repeats (VNTR). Here we report the prevalence of the GPIbalpha gene polymorphisms among Brazilians, a highly ethnically diverse population. We analyzed 492 subjects of European, African, or Indigenous origin. It was possible to determine ten distinct haplotypes. The most common ( reverse similar 40%) haplotype was the Kozak-TT/HPA-2aa/VNTR-CC for both Caucasian and African descent. However, among Indigenous, Kozak-TT/HPA-2aa/VNTR-CC and Kozak-TC/HPA-2aa/VNTR-CC were equally present. Although a strong linkage disequilibrium between VNTR and HPA-2 polymorphism had also been observed, here we determined incomplete linkage disequilibrium in 10% of subjects from all ethnic groups. VNTR-E, a rare variant...Continue Reading
References
Feb 1, 1992·The Journal of Clinical Investigation·R W KuijpersA E von dem Borne
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·L L Cavalli-SforzaJ Mountain
Jan 1, 1980·American Journal of Physical Anthropology·F L BlackT A Weimer
Apr 25, 1994·Archives of Internal Medicine·W D KniffinF A Anderson
Jan 1, 1996·Immunogenetics·S KaskiJ Partanen
Apr 1, 1996·Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics·K Nakajima, M Ichinose
Dec 13, 1997·Circulation·M MurataY Ikeda
Aug 26, 1998·American Journal of Medical Genetics·V R ArrudaF F Costa
Jan 12, 1999·American Journal of Hematology·K M Aramaki, A P Reiner
Jan 14, 1999·British Journal of Haematology·J CorralV Vicente
Jan 14, 1999·The New England Journal of Medicine·R Ross
Jun 22, 1999·The New England Journal of Medicine·G D Sloop
Dec 20, 1999·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·V CastroV R Arruda
Feb 5, 2000·Stroke; a Journal of Cerebral Circulation·A SonodaK Watanabe
Mar 8, 2000·Proceedings of the National Academy of Sciences of the United States of America·J WareZ M Ruggeri
Nov 9, 2000·Lancet·S S AnandM McQueen
Feb 13, 2001·Blood·M B FrankD S Siscovick
Feb 13, 2001·British Journal of Haematology·F IshidaK Kiyosawa
Jun 22, 2001·Blood·R I BakerG Hankey
Nov 8, 2001·Blood·Y CadroyP Sie
May 7, 2002·Seminars in Thrombosis and Hemostasis·Ulrich BuddeReinhard Schneppenheim
Aug 3, 2002·Nature Reviews. Genetics·Sarah A Tishkoff, Scott M Williams
Nov 2, 2002·Nature Medicine·Zaverio M Ruggeri
Jan 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·Flavia C ParraSérgio D J Pena
Feb 8, 2003·Genomics·Motoki OsawaKazuo Umetsu
Feb 18, 2003·British Journal of Haematology·Petra Jilma-StohlawetzSimon Panzer
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·N F DowlingW C Hooper