Genetic variability of purine nucleoside phosphorylase activity in the mouse: relationship to Np-1 and Np-2

Biochemical Genetics
F F SnyderM J Sparling

Abstract

A survey of 37 inbred strains for erythrocyte purine nucleoside phosphorylase activity showed a greater than threefold range. Six of these strains had significantly greater activity than the others, and all of the high-activity strains had the Np-2 electrophoretic band. The high-purine nucleoside phosphorylase activity trait corresponding to Np-2 was inherited in an autosomal codominant manner and minor differences were apparent in thermal and kinetic properties between low- and high-activity strains. This work provides further support for there being either two structural loci for purine nucleoside phosphorylase, Np-1 and Np-2, or a regulatory-modifier locus.

References

Dec 1, 1978·Biochemical Genetics·T A BremnerR E Kouri
Jun 1, 1977·Biochemical Genetics·P G Board, J E Smith
Sep 1, 1976·The Journal of Clinical Investigation·F F SnyderJ E Seegmiller
Jun 14, 1963·Science·S H BOYERM A NAUGHTON
Dec 1, 1951·Proceedings of the Society for Experimental Biology and Medicine·E S RUSSELLC T HIGGINS

❮ Previous
Next ❯

Citations

Jan 1, 1993·Mammalian Genome : Official Journal of the International Mammalian Genome Society·J P JenuthF F Snyder
Jan 1, 1992·Mammalian Genome : Official Journal of the International Mammalian Genome Society·J H Nadeau, R Cox
Jan 1, 1985·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·C J Soodeen, T A Bremner
Jan 1, 1988·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·E R MablyF F Snyder
Jan 1, 1991·Mammalian Genome : Official Journal of the International Mammalian Genome Society·J H NadeauR Cox

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.