Genetic variability of the human filarial parasite, Wuchereria bancrofti in South India

Acta Tropica
N Pradeep KumarP K Das

Abstract

The genetic variability of the lymphatic filarial parasite Wuchereria bancrofti, from three localities (one urban and two rural areas) in southern India, endemic for filariasis was studied using random amplified polymorphic DNA (RAPD) markers. The RAPD profiles were generated for 21 parasite populations (7 populations from each area), using a 10-mer random primer. The analysis of profiles indicated the existence of considerable genetic variability among parasite populations. The Nei's gene diversity between the individual populations in the 2 areas (one urban and another rural) was comparatively greater (0.3372+/-0.1462 & 0.2830+/-0.1764) than that of populations in another village (0.0490+/-0.1373). The greater genetic diversity among the former areas may be due to human migration, endemicity for long time and drug (diethyl-carbamazine citrate) pressure unlike the populations of latter village where the filariasis is relatively a recent introduction and which was never under active chemotherapy. The Nei's genetic distance was estimated and the phylogenetic tree was constructed using 'UPGMA'. These analyses indicated the prevalence of at least two genetically distinct clusters, among the populations studied, their maximum genet...Continue Reading

References

May 1, 1992·Molecular Ecology·H HadrysB Schierwater
Dec 12, 1997·International Journal for Parasitology·B Singh
Nov 20, 1998·Parasitology·R M CurrieD A Bundy
Mar 9, 2000·Acta Tropica·M A GomesE F Silva
May 29, 2000·Parasitology Today·K D RamaiahH Guyatt

❮ Previous
Next ❯

Citations

Mar 31, 2004·The Lancet Infectious Diseases·Edwin MichaelJames W Kazura
Dec 1, 2009·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·K P PailyP K Das
Feb 7, 2006·Veterinary Parasitology·Robin B Gasser
Sep 2, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Scott T SmallPeter A Zimmerman
May 4, 2011·Memórias do Instituto Oswaldo Cruz·Dhamodharan RamasamyManoj Kumar Das
Oct 21, 2005·Microbiology and Immunology·Yashodhar BhandariMaryada Venkata Rami Reddy
Jan 31, 2020·Frontiers in Genetics·Shannon M HedtkeWarwick N Grant

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Allergy & Infectious Diseases (ASM)

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.