PMID: 20098841Jan 26, 2010Paper

Genetic variability of vascular endothelial growth factor and prognosis of head and neck cancer in a Brazilian population

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
M T RuizEny Maria Goloni-Bertollo

Abstract

Vascular endothelial growth factor (VEGF) is one of the most potent endothelial cell mitogens and plays a critical role in angiogenesis. Polymorphisms in this gene have been evaluated in patients with several types of cancer. The objectives of this study were to determine if there was an association of the -1154G/A polymorphism of the VEGF gene with head and neck cancer and the interaction of this polymorphism with lifestyle and demographic factors. Additionally, the distribution of the VEGF genotype was investigated with respect to the clinicopathological features of head and neck cancer patients. The study included 100 patients with histopathological diagnosis of head and neck squamous cell carcinoma. Patients with treated tumors were excluded. A total of 176 individuals 40 years or older were included in the control group and individuals with a family history of neoplasias were excluded. Analysis was performed after extraction of genomic DNA using the real-time PCR technique. No statistically significant differences between allelic and genotype frequencies of -1154G/A VEGF polymorphism were identified between healthy individuals and patients. The real-time PCR analyses showed a G allele frequency of 0.72 and 0.74 for patient...Continue Reading

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Citations

Jul 16, 2011·Translational Research : the Journal of Laboratory and Clinical Medicine·Mostafa FeghhiMir Saeed Yekaninejad
May 2, 2013·Head & Neck·Alexander GelbardEhab Y Hanna
Jan 6, 2018·Biomedicines·Dario DidonaCarmen Cantisani
Oct 13, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Xiao-Juan NieLi Zhang
Jun 27, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lawson EngGeoffrey Liu

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