Genetic variant for behavioral regulation factor of executive function and its possible brain mechanism in attention deficit hyperactivity disorder

Scientific Reports
Xiao SunYufeng Wang

Abstract

As a childhood-onset psychiatric disorder, attention deficit hyperactivity disorder (ADHD) is complicated by phenotypic and genetic heterogeneity. Lifelong executive function deficits in ADHD are described in many literatures and have been proposed as endophenotypes of ADHD. However, its genetic basis is still elusive. In this study, we performed a genome-wide association study of executive function, rated with Behavioral Rating Inventory of Executive Function (BRIEF), in ADHD children. We identified one significant variant (rs852004, P = 2.51e-08) for the overall score of BRIEF. The association analyses for each component of executive function found this locus was more associated with inhibit and monitor components. Further principle component analysis and confirmatory factor analysis provided an ADHD-specific executive function pattern including inhibit and monitor factors. SNP rs852004 was mainly associated with the Behavioral Regulation factor. Meanwhile, we found the significant locus was associated with ADHD symptom. The Behavioral Regulation factor mediated its effect on ADHD symptom. Functional magnetic resonance imaging (fMRI) analyses further showed evidence that this variant affected the activity of inhibition contro...Continue Reading

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Citations

Sep 4, 2018·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Angie Jiménez, Beatriz Lucas-Molina
Oct 2, 2019·Autism Research : Official Journal of the International Society for Autism Research·Tonje TorskeOle A Andreassen
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Jun 26, 2021·The Journal of Clinical Endocrinology and Metabolism·Shengxin LiuAgnieszka Butwicka

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Methods Mentioned

BETA
PCA

Software Mentioned

HaploReg EpiGenome Browser
mach2qtl
MONI Monitor
PLINK
AMOS
EIGENSOFT4
RoadMap
BRAINEAC

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