Genetic Variant in Long Non-Coding RNA H19 Modulates Its Expression and Predicts Renal Cell Carcinoma Susceptibility and Mortality

Frontiers in Oncology
Qiang CaoZengjun Wang

Abstract

The long non-coding RNA (lncRNA) H19 has been demonstrated to play a crucial role in carcinogenesis, including renal cell carcinoma (RCC). However, the impact of genetic variations in H19 gene on RCC has not been investigated before. In the present study, we sought to evaluate whether genetic polymorphisms in H19 are related to the susceptibility and mortality of RCC. We genotyped four widely studied polymorphisms in H19 and assessed their relationship with susceptibility and prognosis of RCC in a case-control study compromising 1,027 cases and 1,094 controls. The functionality of the important polymorphism was further investigated by real-time polymerase chain reaction and luciferase reporter assay. We found that H19 rs2839698 was significantly associated with risk and prognosis of RCC. Compared with the H19 rs2839698 CC genotype, the variant genotypes (CT/TT) were significantly associated with increased risk of RCC (P = 0.023, OR = 1.21; 95% CI = 1.03-1.45). Besides, patients with variant genotypes (CT/TT) were more likely to develop large tumor (P = 0.003, OR = 1.47; 95% CI = 1.16-1.85) and advanced disease (P = 0.010, OR = 1.59; 95% CI = 1.12-2.26); and had a significantly unfavorable overall survival than those with the rs...Continue Reading

References

Apr 27, 2001·American Journal of Epidemiology·J C SemenzaH Anton-Culver
Jun 30, 2005·The Journal of Biological Chemistry·Nathalie BerteauxEric Adriaenssens
Dec 13, 2005·The New England Journal of Medicine·Herbert T Cohen, Francis J McGovern
Feb 12, 2008·European Urology·Gerald W VerhaeghLambertus A Kiemeney
Feb 26, 2009·Cell·Chris P PontingWolf Reik
May 21, 2010·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Anne GaboryLuisa Dandolo
Apr 15, 2011·Molecular Cancer·Ewan A GibbWan L Lam
Jul 23, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C QinZ Zhang
Dec 6, 2011·Growth Factors·Lynda K Harris, Melissa Westwood
Mar 1, 2012·Nucleic Acids Research·Irina V NovikovaKarissa Y Sanbonmatsu
Sep 24, 2013·Molecular Cell·Amanda N KallenYingqun Huang
Sep 1, 2015·Lancet·Umberto Capitanio, Francesco Montorsi
Aug 20, 2016·Cancer Biomarkers : Section a of Disease Markers·Kaijiong ZhangJinbo Liu
Apr 1, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xiang PanYongqing Lai
May 19, 2018·Cancer Science·Anna Sanchez CalleTakahiro Ochiya
Sep 24, 2018·European Urology·Umberto CapitanioPaul Russo
Jan 9, 2019·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Nov 23, 2019·Bulletin du cancer·Yafen YeAnwen Liu
Dec 7, 2019·Science·Sean E McGearyDavid P Bartel

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping
PCR
transfection

Software Mentioned

SNPfold
RNAfold
SAS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.