Genetic variant of prodynorphin gene is risk factor for methamphetamine dependence

Neuroscience Letters
Akira NomuraShigetoshi Kuroda

Abstract

Previous studies have indicated that genetic factors substantially affect development of substance use disorders, including methamphetamine dependence. Prodynorphin (PDYN) is an opioid peptide precursor that yields dynorphins, endogenous kappa opioid-receptor agonists that play important roles in substance abuse. A physiologically active polymorphism of 1-4 repeats of a 68-bp element in the promoter region of the PDYN gene has been identified. We analyzed this polymorphism of the PDYN gene by a case-control association study in 143 patients with methamphetamine dependence and 209 healthy controls in the Japanese population. A 3- or 4-repeat allele in the PDYN gene promoter was found significantly more frequently in patients with methamphetamine dependence than in controls (chi(2)=9.45, p=0.0021). A 3- or 4-repeat allele in the PDYN gene promoter, which was shown to produce significantly higher transcription activity of the PDYN gene than a 1- or 2-repeat allele, is a genetic risk factor for development of methamphetamine dependence (odds ratio: 1.83, 95% CI=1.24-2.68).

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Citations

Mar 7, 2012·Archives of Toxicology·Márcia CarvalhoMaria de Lourdes Bastos
May 2, 2012·Human Genetics·Orna LevranMary Jeanne Kreek
Nov 17, 2009·Molecular Biology and Evolution·Courtney C BabbittGregory A Wray
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Nov 21, 2020·Neuroscience and Biobehavioral Reviews·Alexandre A GuerinJee Hyun Kim
Jun 9, 2016·Open Access Macedonian Journal of Medical Sciences·Khyber Saify, Mostafa Saadat
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Olga NosovaGeorgy Bakalkin

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