Genetic variant strains of Leishmania (Viannia) braziliensis exhibit distinct biological behaviors

Parasitology Research
Felipe Dutra RêgoCélia Maria Ferreira Gontijo

Abstract

A variety of clinical forms of American cutaneous leishmaniasis (ACL) caused by Leishmania braziliensis, as well as differing immune responses of patients, have been reported for an ACL focus in the state of Minas Gerais, Brazil. In addition, two genetic profiles of L. braziliensis have been described, of which one variant profile (hsp70-variant) has been associated with atypical lesions. We investigated the biological behavior of genetic variant strains of L. braziliensis isolated from patients with different clinical manifestations of ACL. Experimental infections were performed with golden hamsters for five L. braziliensis strains in standardized doses of 1 × 106 parasites per inocula. The characteristics of skin lesions, histopathological features, and parasite burden were independently analyzed at 30 and 60 days post-infection. The data revealed distinct patterns in the onset time of visible skin lesions as well as in lesion size and parasite burden among the strains. The extent and density of the inflammatory infiltrate differed among strains, although cellular composition of granulomas appeared similar. Multivariate analysis indicated the occurrence of two clusters: one comprising native strains (cluster 1) and one compri...Continue Reading

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Citations

Nov 13, 2020·Frontiers in Cellular and Infection Microbiology·Luz H PatinoJuan David Ramírez
Aug 3, 2021·Frontiers in Cellular and Infection Microbiology·Amanda Gubert Alves Dos SantosGessilda de Alcantara Nogueira-Melo

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Methods Mentioned

BETA
optical microscopy
PCR

Software Mentioned

AxioVision
GraphPad Prism
GraphPad
SPSS

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